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Now showing items 1-20 of 65

Laundry detergent compatibility of the alkaline protease from Bacillus cereus

Banik, R.M.; Prakash, M. (Elsevier GmbH, 2004-06-30)

The endogenous protease activity in various commercially available laundry detergents of international companies was studied. The maximum protease activity was found at 50°C in pH range 10.5-11.0 in all the tested laundry ...
IMPROVED GROWTH AND COLCHICINE CONCENTRATION IN GLORIOSA SUPERBA ON MYCORRHIZAL INOCULATION SUPPLEMENTED WITH PHOSPHORUS-FERTILIZER

Pandey, Devendra Kumar; Malik, Tabarak; Dey, Abhijit; and et. al. (2014)

BACKGROUND: Gloriosa superba produces an array of alkaloids including colchicine, a compound of interest in the treatment of various diseases. The tuber of Gloriosa superba is a rich source of colchicine which has shown ...
Striking the right balance determines TB or not TB

Dasgupta, Somdeb Bose; Pieters, Jean (Frontiers Media S.A., 2014-10)

Mycobacterium tuberculosis continues to be one of the most successful pathogens on earth. Upon inhalation of M. tuberculosis by a healthy individual, the host immune system will attempt to eliminate these pathogens using ...
Evaluation of poly(L-lactide) and chitosan composite scaffolds for cartilage tissue regeneration

Mallick, Sarada Prasanna; Pal, Kunal; Rastogi, Amit; Srivastava, Pradeep (Taylor and Francis Ltd., 2016-02-01)

The present study delineates the development of chitosan and poly(L-lactide) (PLLA) scaffolds cross-linked using a mixture of 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC), n-hydroxysuccinimide (NHS), ...
Improved production of Daptomycin in an airlift bioreactor by morphologically modified and immobilized cells of Streptomyces roseosporus

Chakravarty, Ipsita; Kundu, Subir (Springer Verlag, 2016-12-01)

The increased threat of drug resistance has challenged the existence of several conventional and non-conventional antibiotics in the recent times. Daptomycin is a novel cyclic-lipopeptide antibiotic produced by Streptomyces ...
Optimization and partial characterization of intracellular anticandidal protein from Aspergillus giganteus MTCC 8408 using taguchi DOE

Dutta, Debashis; Das, Mira Debnath (Taylor and Francis Inc., 2017-11-03)

A new intracellular antifungal protein (afp) production with average molecular weight 24.3 kDa and yield of 0.65 ± 0.1 mg/gram dry cell weight (gdcw) of mycelia in submerged fermentation of Aspergillus giganteus MTCC 8408 ...
Preparation of Drug Eluting Natural Composite Scaffold Using Response Surface Methodology and Artificial Neural Network Approach

Shera, S.S.; Sahu, S.; Banik, R.M. (Korean Tissue Engineering and Regenerative Medicine Society, 2018-04-01)

Silk fibroin/xanthan composite was investigated as a suitable biomedical material for controlled drug delivery, and blending ratios of silk fibroin and xanthan were optimized by response surface methodology (RSM) and ...
Optimization of Process Parameters for Cholesterol Oxidase Production by Streptomyces Olivaceus MTCC 6820

Sahu, Shraddha; Shera, Shailendra Singh; Banik, Rathindra Mohan (Bentham Science Publishers, 2019-03-26)

Background: Streptomyces olivaceus MTCC 6820 is a potent microorganism for cholesterol oxidase (ChOx) production through the submerged fermentation process. Statistical optimization of the process parameters for submerged ...
Enhanced reusability of horseradish peroxidase immobilized onto graphene oxide/magnetic chitosan beads for cost effective cholesterol oxidase assay

Sahu, Shraddha; Shera, Shailendra Singh; Banik, Rathindra Mohan (Bentham Science Publishers, 2019-06-19)

Background: Horseradish Peroxidase (HRP) is an important biocatalyst extensively used in enzymatic reactions. Cholesterol oxidase (ChoX) is a commercially valuable enzyme used in the estimation of cholesterol in human ...
Identification of lead molecules against potential drug target protein MAPK4 from L. Donovani: An in-silico approach using docking, molecular dynamics and binding free energy calculation

Raj, S.; Sasidharan, S.; Dubey, V.K.; Saudagar, P. (Public Library of Science, 2019-08-01)

Leishmaniasis caused by obligate intracellular parasites of genus Leishmania is one of the most neglected tropical diseases threatening 350 million people worldwide. Protein kinases have drawn much attention as potential ...
Biochemical characterization and chemical validation of Leishmania MAP Kinase-3 as a potential drug target

Raj, Shweta; Saha, Gundappa; Sasidharan, Santanu; Dubey, Vikash Kumar; Saudagar, Prakash (Nature Publishing Group, 2019-12-01)

Protozoan parasites of the Leishmania genus have evolved unique signaling pathways that can sense various environmental changes and trigger stage differentiation for survival and host infectivity. MAP kinase (MAPK) plays ...
Green synthesis of silver nanoparticles from Tectona grandis seeds extract

Rautela, Akhil; Rani, Jyoti; Debnath Das, Mira (Springer, 2019-12-01)

Green synthesis of silver nanoparticles makes use of plant constituents, like carbohydrates, fats, enzymes, flavonoids, terpenoids, polyphenols, and alkaloids, as reducing agents to synthesize silver nanoparticles. The ...
Effect of purified alkaline phosphatase from Bacillus licheniformis on growth of Zea mays L.

Singh, P.; Banik, R.M. (Horizon e-Publishing Group, 2019-12-31)

Some soil microbes have the capability to solubilize mineral phosphate into organic phosphorous and used as biofertilizer to improve crop productivity in agricultural field. In this study, phosphate solubilization assay ...
Development of BSA conjugated on modified surface of quercetin-loaded lipid nanocarriers for breast cancer treatment

Kumar, R.; Choudhary, D.K.; Debnath, M. (Institute of Physics Publishing, 2020)

Multiple drug resistance is a key limitation for the clinical administration of chemotherapeutic drugs, apart from this their major limitations with free drugs are poor solubility, physiochemical and pharmaceutical behavior. ...
Identification of new anti-nCoV drug chemical compounds from Indian spices exploiting SARS-CoV-2 main protease as target

Umesh, U.; Kundu, D.; Selvaraj, C.; Singh, S.K.; Dubey, V.K. (Taylor and Francis Ltd., 2020)

The 2019-novel coronavirus (nCoV) has caused a global health crisis by causing coronavirus disease-19 (COVID-19) pandemic in the human population. The unavailability of specific vaccines and anti-viral drug for nCoV, science ...
Leucoefdin a potential inhibitor against SARS CoV-2 Mpro

Singh, A.; Mishra, A. (Taylor and Francis Ltd., 2020)

Leucoefdin an important constituent of various fruits such as banana, raspberry, etc. was explored to target MPro protease of SARS Co-V 2. Ligand was found to bind at active site of MPro with large negative binding energies ...
Bacterial protein azurin and derived peptides as potential anti-SARS-CoV-2 agents: insights from molecular docking and molecular dynamics simulations

Sasidharan, S.; Selvaraj, C.; Singh, S.K.; Dubey, V.K.; Kumar, S.; Fialho, A.M.; Saudagar, P. (Taylor and Francis Ltd., 2020)

The current pandemic SARS-CoV-2 has wreaked havoc in the world, and neither drugs nor vaccine is available for the treatment of this disease. Thus, there is an immediate need for novel therapeutics that can combat this ...
Effect of protease inhibitor from Agaricus bisporus on glucose uptake and oxidative stress in 3T3-L1 adipocytes

Vishvakarma, R.; Mishra, A. (Wolters Kluwer Medknow Publications, 2020-03-01)

Objective: To explore the effect of the protease inhibitor from Agaricus bisporus (J.E. Lange) Imbach (AbPI) on glucose uptake and oxidative stress in 3T3-L1 adipocytes. Methods: Adipocytes were differentiated and stained ...
Multi-objective optimization of media components for improved algae biomass, fatty acid and starch biosynthesis from Scenedesmus sp. ASK22 using desirability function approach

Pandey, A.; Gupta, A.; Sunny, A.; Kumar, S.; Srivastava, S. (Elsevier Ltd, 2020-05)

In this study, we sought to improve medium composition for enhanced biomass, lipid and starch content by using response surface methodology and composite desirability function approach for the heterotrophic cultivation of ...
TMLRpred: A machine learning classification model to distinguish reversible EGFR double mutant inhibitors

Saini, R.; Fatima, S.; Aggarwal, S.M. (Blackwell Publishing Ltd, 2020-09-01)

The EGFR is a clinically important therapeutic drug target in lung cancer. The first-generation tyrosine kinase inhibitors used in clinics are effective against L858R-mutated EGFR. However, relapse of the disease due to ...

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