• Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFRCSTMLR mutant protein: molecular modeling and free energy approach 

  Saini, Ravi; Kumari, Sonali; Bhatnagar, Aditi; Singh, Amit; Mishra, Abha (Nature Research, 2023-06-01)

  EGFR (epidermal growth factor receptor), a surface protein on the cell, belongs to the tyrosine kinase family, responsible for cell growth and proliferation. Overexpression or mutation in the EGFR gene leads to various ...
• Chemically engineered unzipped multiwalled carbon nanotube and rGO nanohybrid for ultrasensitive picloram detection in rice water and soil samples 

  Dkhar, Daphika S.; Kumari, Rohini; Chandra, Pranjal (Nature Research, 2023-06-19)

  Picloram (4-Amino-3,5,6-trichloro pyridine-2-carboxylic acid) is a chlorinated herbicide that has been discovered to be tenacious and relatively durable in both soil and water. It is known to have adverse and unpleasant ...
• Dual-target drugs against Leishmania donovani for potential novel therapeutics 

  Bora, Kushal; Sarma, Manash; Kanaujia, Shankar Prasad; Dubey, Vikash Kumar (Nature Research, 2023-10-26)

  Antioxidant defense mechanisms are important for a parasite to overcome oxidative stress and survive within host macrophage cells. Mitochondrial iron superoxide dismutase A (FeSODA) and trypanothione reductase (TR) are ...
• Bioinspired and biomimetic cancer-cell-derived membrane nanovesicles for preclinical tumor-targeted nanotheranostics 

  Prasad, Rajendra; Mendes, Bárbara B.; Gorain, Mahadeo; Chandra Kundu, Gopal; Gupta, Narendra; Peng, Berney; Aung Win, Eaint Honey; Qing, He; Conde, João (Cell Press, 2023-11-15)

  Bioinspired cell-membrane-camouflaged nanohybrids have been proposed to enhance tumor targeting by harnessing their immune escape and self-recognition abilities. In this study, we introduce cancer-cell-derived membrane ...
• Multi-pathogen based chimeric vaccine to fight against COVID-19 and concomitant coinfections 

  Ojha, Rupal; Singh, Satyendra; Gupta, Nidhi; Kumar, Ketan; Padhi, Aditya K.; Prajapati, Vijay Kumar (Springer Science and Business Media B.V., 2023-05-06)

  Background: COVID-19 has proved to be a fatal disease of the year 2020, due to which thousands of people globally have lost their lives, and still, the infection cases are at a high rate. Experimental studies suggested ...
• Real-time assessment of the Ganga river during pandemic COVID-19 and predictive data modeling by machine learning 

  Singh, J.; Swaroop, S.; Sharma, P.; Mishra, V. (Institute for Ionics, 2023-07)

  In this study, four water quality parameters were reviewed at 14 stations of river Ganga in pre-, during and post-lockdown and these parameters were modeled by using different machine learning algorithms. Various mathematical ...
• Development of predictive model for the fixed-bed column reactor 

  Singh, Jyoti; Kumaresan, Santhosh Kumar; Swaroop, Sarvanshi; Mishra, Vishal (Springer Science and Business Media Deutschland GmbH, 2023-04-17)

  The present study aims at development of a mathematical model for the fixed-bed column adsorption that relates the reactor parameters with the breakthrough curve. Effects of operating parameters like bed height, flow rate, ...
• Geranyl Diphosphate Synthase (CrtE) Inhibition Using Alendronate Enhances Isoprene Production in Recombinant Synechococcus elongatus UTEX 2973: A Step towards Isoprene Biorefinery 

  Yadav, Indrajeet; Rautela, Akhil; Gangwar, Agendra; Kesari, Vigya; Padhi, Aditya K.; Kumar, Sanjay (MDPI, 2023-02-24)

  A hemiterpene, isoprene, is commercially produced from crude oil refining processes. As a result of fossil fuel depletion, isoprene production process development is gaining attention from recombinant cyanobacteria and ...
• Electrochemical Nano-Imprinting of Trimetallic Dendritic Surface for Ultrasensitive Detection of Cephalexin in Pharmaceutical Formulations 

  Kumari, Rohini; Chandra, Pranjal (Multidisciplinary Digital Publishing Institute (MDPI), 2023-03-08)

  Cephalexin (CFX), a first-generation cephalosporin, is used to treat various infectious diseases. Although antibiotics have achieved considerable progress in the eradication of infectious diseases, their incorrect and ...
• Clinically Deployable Bioelectronic Sensing Platform for Ultrasensitive Detection of Transferrin in Serum Sample 

  Kaur, Harleen; Chittineedi, Prasanthi; Bellala, Ravi Shankar; Bellala, Venkata Madhavi; Singh, Sandeep; Kumari, Rohini; Chandra, Pranjal; Pandrangi, Santhi Latha; Singh, Surinder P. (Multidisciplinary Digital Publishing Institute (MDPI), 2023-03-23)

  Varying levels of transferrin (Tf) have been associated with different disease conditions and are known to play a crucial role in various malignancies. Regular monitoring of the variations in Tf levels can be useful for ...
• Comprehensive analysis of liquid–liquid phase separation propensities of HSV-1 proteins and their interaction with host factors 

  Subedi, Sushma; Nag, Niharika; Shukla, Harish; Padhi, Aditya K.; Tripathi, Timir (John Wiley and Sons Inc, 2023-10-05)

  In recent years, it has been shown that the liquid–liquid phase separation (LLPS) of virus proteins plays a crucial role in their life cycle. It promotes the formation of viral replication organelles, concentrating viral ...
• Impaired tissue homing by the Ikzf3N159S variant is mediated by interfering with Ikaros function 

  Chang, Jingjie; Yamashita, Motoi; Padhi, Aditya K.; Zhang, Kam Y. J.; Taniuchi, Ichiro (Frontiers Media SA, 2023-08-17)

  AIOLOS, encoded by IKZF3, is a member of the IKZF family of proteins that plays an important role in regulating late B-cell differentiation. Human individuals heterozygous for the AIOLOS p.N160S variant displayed impaired ...
• Drug Encapsulated Lipid-Polymeric Nanohybrid as a Chemo-therapeutic Platform of Cancer 

  Kumar, Rahul; Ranjan Srivastava, Vinish; Mahapatra, Supratim; Dkhar, Daphika S.; Kumari, Rohini; Darshna; Prerna, Kumari; Dubey, Vikash Kumar; Chandra, Pranjal (Ivyspring International Publisher, 2023-01-16)

  The focus of this research is to design a bioengineered drug delivery vehicle that is efficient in anti-cancer drug delivery in a controlled manner. The experimental work focuses on constructing a methotrexate-loaded nano ...
• Repurposing of FDA-approved drugs as autophagy inhibitors in tumor cells 

  Prerna, Kumari; Dubey, Vikash Kumar (Taylor and Francis Ltd. CODEN, 2022)

  Autophagy and apoptosis are the two crucial processes of programmed cell death found in all eukaryotic cells; however, the elevated physiological stress in the tumor microenvironment leads to uncontrolled up-regulation in ...
• Flavonoids as Promising Neuroprotectants and Their Therapeutic Potential against Alzheimer's Disease 

  Minocha, Tarun; Birla, Hareram; Obaid, Ahmad A.; Rai, Vipin; Sushma P.; Shivamallu, Chandan; Moustafa, Mahmoud; Al-Shehri, Mohammed; Al-Emam, Ahmed; Tikhonova, Maria A.; Yadav, Sanjeev Kumar; Poeggeler, Burkhard (Hindawi Limited, 2022)

  Alzheimer's disease (AD) is one of the serious and progressive neurodegenerative disorders in the elderly worldwide. Various genetic, environmental, and lifestyle factors are associated with its pathogenesis that affect ...
• The third international hackathon for applying insights into large-scale genomic composition to use cases in a wide range of organisms 

  Walker, Kimberly; Kalra, Divya; Lowdon, Rebecca; Chen, Guangyi; Sedlazeck, Fritz J; Busby, Ben; Molik, David; Soto, Daniela C.; Dabbaghie, Fawaz; Khleifat, Ahmad Al; Mahmoud, Medhat; Paulin, Luis F. (F1000 Research Ltd, 2022)

  In October 2021, 59 scientists from 14 countries and 13 U.S. states collaborated virtually in the Third Annual Baylor College of Medicine & DNANexus Structural Variation hackathon. The goal of the hackathon was to advance ...
• Computational Protein Design for COVID-19 Research and Emerging Therapeutics 

  Kalita, Parismita; Tripathi, Timir; Padhi, Aditya K. (American Chemical Society, 2022)

  As the world struggles with the ongoing COVID-19 pandemic, unprecedented obstacles have continuously been traversed as new SARS-CoV-2 variants continually emerge. Infectious disease outbreaks are unavoidable, but the ...
• Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry 

  Singh, Sumit K.; Lee, Kelvin H. (Frontiers Media S.A., 2022-01-11)

  Glycosylation is a critical quality attribute of monoclonal antibody (mAb) therapeutics. Hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) is an invaluable technology for the characterization of ...
• Ultrasensitive Aptasensors for the Detection of Viruses Based on Opto-Electrochemical Readout Systems 

  Divya; Dkhar, Daphika S.; Kumari, Rohini; Mahapatra, Supratim; Kumar, Rahul; Chandra, Pranjal (MDPI, 2022-02)

  Viral infections are becoming the foremost driver of morbidity, mortality and economic loss all around the world. Treatment for diseases associated to some deadly viruses are challenging tasks, due to lack of infrastructure, ...
• Advancements in applicability of microbial fuel cell for energy recovery from human waste 

  Verma, Manisha; Verma, Manoj Kumar; Singh, Veer; Singh, Jyoti; Singh, Vishal; Mishra, Vishal (Elsevier Ltd, 2022-02)

  Microbial fuel cells (MFCs) technology is frequently conferred as a division of wastewater treatment along with electricity generation. Specifically, the application of MFCs for energy recovery from the waste is also great ...

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