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Advancements in applicability of microbial fuel cell for energy recovery from human waste

Verma, Manisha; Verma, Manoj Kumar; Singh, Veer; Singh, Jyoti; Singh, Vishal; Mishra, Vishal (Elsevier Ltd, 2022-02)

Microbial fuel cells (MFCs) technology is frequently conferred as a division of wastewater treatment along with electricity generation. Specifically, the application of MFCs for energy recovery from the waste is also great ...
Bacterial protein azurin and derived peptides as potential anti-SARS-CoV-2 agents: insights from molecular docking and molecular dynamics simulations

Sasidharan, S.; Selvaraj, C.; Singh, S.K.; Dubey, V.K.; Kumar, S.; Fialho, A.M.; Saudagar, P. (Taylor and Francis Ltd., 2020)

The current pandemic SARS-CoV-2 has wreaked havoc in the world, and neither drugs nor vaccine is available for the treatment of this disease. Thus, there is an immediate need for novel therapeutics that can combat this ...
Biochemical characterization and chemical validation of Leishmania MAP Kinase-3 as a potential drug target

Raj, Shweta; Saha, Gundappa; Sasidharan, Santanu; Dubey, Vikash Kumar; Saudagar, Prakash (Nature Publishing Group, 2019-12-01)

Protozoan parasites of the Leishmania genus have evolved unique signaling pathways that can sense various environmental changes and trigger stage differentiation for survival and host infectivity. MAP kinase (MAPK) plays ...
Bioinspired and biomimetic cancer-cell-derived membrane nanovesicles for preclinical tumor-targeted nanotheranostics

Prasad, Rajendra; Mendes, Bárbara B.; Gorain, Mahadeo; Chandra Kundu, Gopal; Gupta, Narendra; Peng, Berney; Aung Win, Eaint Honey; Qing, He; Conde, João (Cell Press, 2023-11-15)

Bioinspired cell-membrane-camouflaged nanohybrids have been proposed to enhance tumor targeting by harnessing their immune escape and self-recognition abilities. In this study, we introduce cancer-cell-derived membrane ...
Characterization of Monoclonal Antibody Glycan Heterogeneity Using Hydrophilic Interaction Liquid Chromatography-Mass Spectrometry

Singh, Sumit K.; Lee, Kelvin H. (Frontiers Media S.A., 2022-01-11)

Glycosylation is a critical quality attribute of monoclonal antibody (mAb) therapeutics. Hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) is an invaluable technology for the characterization of ...
Chemically engineered unzipped multiwalled carbon nanotube and rGO nanohybrid for ultrasensitive picloram detection in rice water and soil samples

Dkhar, Daphika S.; Kumari, Rohini; Chandra, Pranjal (Nature Research, 2023-06-19)

Picloram (4-Amino-3,5,6-trichloro pyridine-2-carboxylic acid) is a chlorinated herbicide that has been discovered to be tenacious and relatively durable in both soil and water. It is known to have adverse and unpleasant ...
Clinically Deployable Bioelectronic Sensing Platform for Ultrasensitive Detection of Transferrin in Serum Sample

Kaur, Harleen; Chittineedi, Prasanthi; Bellala, Ravi Shankar; Bellala, Venkata Madhavi; Singh, Sandeep; Kumari, Rohini; Chandra, Pranjal; Pandrangi, Santhi Latha; Singh, Surinder P. (Multidisciplinary Digital Publishing Institute (MDPI), 2023-03-23)

Varying levels of transferrin (Tf) have been associated with different disease conditions and are known to play a crucial role in various malignancies. Regular monitoring of the variations in Tf levels can be useful for ...
Clinically practiced and commercially viable nanobio engineered analytical methods for COVID-19 diagnosis

Mahapatra, S.; Chandra, P. (Elsevier Ltd, 2020-10-01)

The recent outbreak of the coronavirus disease (COVID-19) has left the world clueless. As the WHO declares this new contagion as a pandemic on the 11th of March 2020, the alarming rate of the spawn of the disease in such ...
Comprehensive analysis of liquid–liquid phase separation propensities of HSV-1 proteins and their interaction with host factors

Subedi, Sushma; Nag, Niharika; Shukla, Harish; Padhi, Aditya K.; Tripathi, Timir (John Wiley and Sons Inc, 2023-10-05)

In recent years, it has been shown that the liquid–liquid phase separation (LLPS) of virus proteins plays a crucial role in their life cycle. It promotes the formation of viral replication organelles, concentrating viral ...
Computational identification of natural product inhibitors against EGFR double mutant (T790M/L858R) by integrating ADMET, machine learning, molecular docking and a dynamics approach

Agarwal, Subhash M; Nandekar, Prajwal; Saini, Ravi (Royal Society of Chemistry, 2022-06)

Double mutated epidermal growth factor receptor is a clinically important target for addressing drug resistance in lung cancer treatment. Therefore, discovering new inhibitors against the T790M/L858R (TMLR) resistant ...
Computational Protein Design for COVID-19 Research and Emerging Therapeutics

Kalita, Parismita; Tripathi, Timir; Padhi, Aditya K. (American Chemical Society, 2022)

As the world struggles with the ongoing COVID-19 pandemic, unprecedented obstacles have continuously been traversed as new SARS-CoV-2 variants continually emerge. Infectious disease outbreaks are unavoidable, but the ...
Curcumin, a traditional spice component, can hold the promise against COVID-19?

Soni, V.K.; Mehta, A.; Ratre, Y.K.; Tiwari, A.K.; Amit, A.; Singh, R.P.; Sonkar, S.C.; Chaturvedi, N.; Shukla, D.; Vishvakarma, N.K. (Elsevier B.V, 2020-11-05)

The severity of the recent pandemic and the absence of any specific medication impelled the identification of existing drugs with potential in the treatment of Coronavirus disease-2019 (COVID-19), caused by severe acute ...
Curcumin, a traditional spice component, can hold the promise against COVID-19?

Soni, V.K.; Mehta, A.; Ratre, Y.K.; Tiwari, A.K.; Amit, A.; Singh, R.P.; Sonkar, S.C.; Chaturvedi, N.; Shukla, D.; Vishvakarma, N.K. (Elsevier B.V., 2020-11-05)

The severity of the recent pandemic and the absence of any specific medication impelled the identification of existing drugs with potential in the treatment of Coronavirus disease-2019 (COVID-19), caused by severe acute ...
Deciphering the gut microbiome in neurodegenerative diseases and metagenomic approaches for characterization of gut microbes

Singh, Nidhi; Singh, Veer; Rai, Sachchida Nand; Mishra, Vishal; Vamanu, Emanuel; Singh, Mohan P. (Elsevier Masson s.r.l., 2022-12)

The central nervous system has essential role in the regulation of the physiological condition of the human body. Gut microbes cause several types of gastrointestinal diseases like ulcer stomach and intestine and irritable ...
Design and Engineering of a Palm-Sized Optical Immunosensing Device for the Detection of a Kidney Dysfunction Biomarker

Mahapatra, Supratim; Chandra, Pranjal; Divya (MDPI, 2022-12)

Creatinine is one of the most common and specific biomarkers for renal diseases, usually found in the serum and urine of humans. Its level is extremely important and critical to know, not only in the case of renal diseases, ...
Design strategies for composite matrix and multifunctional polymeric scaffolds with enhanced bioactivity for bone tissue engineering

Kumari, Shikha; Katiyar, Soumya; Darshna; Anand, Aditya; Singh, Divakar; Singh, Bhisham Narayan; Mallick, Sarada Prasanna; Mishra, Abha; Srivastava, Pradeep (Frontiers Media S.A., 2022-11-28)

Over the past few decades, various bioactive material-based scaffolds were investigated and researchers across the globe are actively involved in establishing a potential state-of-the-art for bone tissue engineering ...
Development of BSA conjugated on modified surface of quercetin-loaded lipid nanocarriers for breast cancer treatment

Kumar, R.; Choudhary, D.K.; Debnath, M. (Institute of Physics Publishing, 2020)

Multiple drug resistance is a key limitation for the clinical administration of chemotherapeutic drugs, apart from this their major limitations with free drugs are poor solubility, physiochemical and pharmaceutical behavior. ...
Development of predictive model for the fixed-bed column reactor

Singh, Jyoti; Kumaresan, Santhosh Kumar; Swaroop, Sarvanshi; Mishra, Vishal (Springer Science and Business Media Deutschland GmbH, 2023-04-17)

The present study aims at development of a mathematical model for the fixed-bed column adsorption that relates the reactor parameters with the breakthrough curve. Effects of operating parameters like bed height, flow rate, ...
Discovery of Histone Deacetylase Inhibitor Using Molecular Modeling and Free Energy Calculations

Mishra, Abha; Singh, Amit (American Chemical Society, 2022-05)

The histone acetylation-deacetylation at lysine regulates the functions of many cellular proteins. An increased expression of HDAC6 can cause an increased amount of deacetylated histones, which leads to an inhibition of ...
Discovery of the allosteric inhibitor from actinomyces metabolites to target EGFRCSTMLR mutant protein: molecular modeling and free energy approach

Saini, Ravi; Kumari, Sonali; Bhatnagar, Aditi; Singh, Amit; Mishra, Abha (Nature Research, 2023-06-01)

EGFR (epidermal growth factor receptor), a surface protein on the cell, belongs to the tyrosine kinase family, responsible for cell growth and proliferation. Overexpression or mutation in the EGFR gene leads to various ...

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