Department of Pharmaceutical Engineering: Recent submissions

Now showing items 121-140 of 178

Synthesis, characterization, antimicrobial and cytotoxicity evaluation of quaternary cadmium (II)-quercetin complexes with 1,10-phenanthroline or 2,2’-bipyridine ligands

Srivastava, T.; Mishra, S.K.; Tiwari, O.P.; Kumar, A.; Tiwari, K.N.; Kumar, P.; Dixit, J.; Kumar, J.; Singh, A.K.; Verma, P.; Saini, R.; Singh, A.; Dwivedi, A.K. (Taylor and Francis Ltd., 2020-01-01)

This study reports the synthesis and antibacterial evaluation of two novel complexes, [Cd (Q) (Bpy) (CH3COO)2, complex 1] and [Cd (Q) (Phen) (CH3COO)2, complex 2], based on quercetin ligand. The method of synthesis was by ...
Small molecule therapeutics for tauopathy in Alzheimer's disease: Walking on the path of most resistance

Wang, L.; Bharti; Kumar, R.; Pavlov, P.F.; Winblad, B. (Elsevier Masson s.r.l., 2020)

Alzheimer's disease (AD) is the most common form of dementia characterized by presence of extracellular amyloid plaques and intracellular neurofibrillary tangles composed of tau protein. Currently there are close to 50 ...
Mannose receptor targeted bioadhesive chitosan nanoparticles of clofazimine for effective therapy of tuberculosis

Pawde, D.M.; Viswanadh, M.K.; Mehata, A.K.; Sonkar, R.; Narendra; Poddar, S.; Burande, A.S.; Jha, A.; Vajanthri, K.Y.; Mahto, S.K.; Azger Dustakeer, V.N.; Muthu, M.S. (Elsevier B.V., 2020)

Drug-resistant tuberculosis (TB) is one of the most lethal diseases, and it is imperative to exploit an advanced drug formulation for its effective treatment. This work aims to develop a mannose receptor-targeted bioadhesive ...
Drug repurposing for Alzheimer’s disease: in silico and in vitro investigation of FDA-approved drugs as acetylcholinesterase inhibitors

Kumar, N.; Gahlawat, A.; Kumar, R.N.; Singh, Y.P.; Modi, G.; Garg, P. (Taylor and Francis Ltd., 2020)

Alzheimer’s disease (AD) is one of the most familiar multifactorial and complex neurodegenerative disorders characterized by loss of cholinergic neurons in the brain. The various attempts for drug development to treat AD ...
Virtual screening and molecular simulation study of natural products database for lead identification of novel coronavirus main protease inhibitors

Tripathi, N.; Goel, B.; Bhardwaj, N.; Sahu, B.; Kumar, H.; Jain, S.K. (Taylor and Francis Ltd., 2020)

3CL like protease (3CLpro or Mpro) is one of the main proteases of 2019-nCoV. The 3CLpro is a nonstructural protein of SARS-CoV and has an essential role in viral replication and transcription, thus, could be a potential ...
Exploration of dual fatty acid amide hydrolase and cholinesterase inhibitory potential of some 3-hydroxy-3-phenacyloxindole analogs

Tripathi, R.K.P.; Ayyannan, S.R. (Wiley-VCH Verlag, 2020-09-01)

The dual inhibition of fatty acid amide hydrolase (FAAH) and cholinesterases (ChEs) has recently egressed as a novel strategy for the management of neurodegeneration. In the present work, a library of 3-hydroxy-3-phenacyloxindole ...
Design, synthesis, and multitargeted profiling of N-benzylpyrrolidine derivatives for the treatment of Alzheimer's disease

Choubey, P.K.; Tripathi, A.; Sharma, P.; Shrivastava, S.K. (Elsevier Ltd, 2020-11)

Multitarget molecular hybrids of N-benzyl pyrrolidine derivatives were designed, synthesized, and biologically evaluated for the treatment of Alzheimer's disease (AD). Among the synthesized compounds, 4k and 4o showed ...
Dendritic cell-targeted theranostic nanomedicine: Advanced cancer nanotechnology for diagnosis and therapy

Mehata, A.K.; Viswanadh, M.K.; Priya, V.; Vikas, V.; Muthu, M.S. (Future Medicine Ltd., 2020-04)

No abstract available
The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives

Quoc Lam, B.; Shrivastava, S.K.; Shrivastava, A.; Shankar, S.; Srivastava, R.K. (Blackwell Publishing Inc., 2020-07-01)

The incidence of obesity and type 2 diabetes (T2DM) in the Western world has increased dramatically during the recent decades. According to the American Cancer Society, pancreatic cancer (PC) is the fourth leading cause ...
Correction to: EGFR Targeted Paclitaxel and Piperine Co-loaded Liposomes for the Treatment of Triple Negative Breast Cancer (AAPS PharmSciTech, (2020), 21, 5, (151), 10.1208/s12249-020-01671-7)

Burande, A.S.; Viswanadh, M.K.; Jha, A.; Mehata, A.K.; Shaik, A.; Agrawal, N.; Poddar, S.; Mahto, S.K.; Muthu, M.S. (Springer, 2020-08-01)

As the authors were working on similar projects on liposomes at the same time, the 3D figures of Fig. 3 bi and Fig. 3 bii were inadvertently misplaced. © 2020, American Association of Pharmaceutical Scientists.
Lapatinib-loaded nanocolloidal polymeric micelles for the efficient treatment of breast cancer

Bonde, G.V.; Ajmal, G.; Yadav, S.K.; Mittal, P.; Mishra, B. (Open Science Publishers LLP Inc., 2020-09-01)

This study aims at preparing and evaluating lapatinib-loaded polymeric micelles for the better treatment of breast cancer (BC). LP-loaded polymeric micelles (LP-PMs) were prepared as per our previous studies by using ...
Doxycycline Poly E-Caprolactone Nanofibers in Patients with Chronic Periodontitis – A Clinical Evaluation

Chaturvedi, T.P.; Srivastava, Ruchi; Srivastava, A.K.; and et al. (JCDR Research and Publications (Pvt) Limited, 2013-10)

Aim: To develop a low-dose controlled-release delivery system for the treatment of periodontal infections. A new sustained release drug system of Poly e-caprolactone (PCL) nanofibers containing doxycycline (DOX) was ...
Quality control studies of argyreia speciosa sweet leaves

Sahu, Alakh, N; Hemalatha, S; Sairam, K. (Moksha Publishing House, 2013-07-11)

The plant Argyreia speciosa Sweet (Syn: Argyreia nervosa Burm. f.), is a woody climber which belongs to the family Convulvulaceae. The plant is commonly known as Elephant creeper in English and in Hindi, it is known as ...
HPTLC fingerprinting and in vitro antioxidant studies of argyreia speciosa sweet leaves and mesua ferrea linn. flowers

Sahu, Alakh, N.; Hemalatha, S.; Sairam, K. (Moksha Publishing House, 2013-07-20)

Natural antioxidants present in plants have attracted interest because of their safety and potential nutritional and therapeutic effects. The plant kingdom offers a wide range of natural antioxidants. The HPTLC fingerprinting ...
Development and Evaluation of Solid Lipid Nanoparticles of Raloxifene Hydrochloride for Enhanced Bioavailability

Kushwaha, Anand Kumar; Vuddanda, Parameswara Rao; Karunanidhi, Priyanka; and et al. (Hindawi Publishing Corporation, 2013-08-13)

Raloxifene hydrochloride (RL-HCL) is an orally selective estrogen receptor modulator (SERM) with poor bioavailability of nearly 2% due to its poor aqueous solubility and extensive first pass metabolism. In order to improve ...
Gelucire Based In Situ Gelling Emulsions

Saxena, Ashwin; Mishra, Arun K.; Verma, Navneet; and et al. (Hindawi, 2013-09-19)

Non steroidal anti-inflammatory drugs (NSAIDs) are commonly prescribed medications to the geriatric patients for the treatment of arthritis and other painful disorders. The major side effects of NSAIDs are related to their ...
Investigations on Agglomeration and Haemocompatibility of Vitamin E TPGS Surface Modified Berberine Chloride Nanoparticles

Vuddanda, Parameswara Rao; Rajamanickam, Vijayakumar Mahalingam; Yaspal, Madhu; and et. al. (Hindawi Publishing Corporation, 2014-08-04)

The objective of the present study is to investigate the influence of surface modification on systemic stability of NPs. Vitamin E TPGS (1% w/v) was used for surface modification of berberine chloride nanoparticles. Naked ...
Intestinal Lymphatic Delivery of Praziquantel by Solid Lipid Nanoparticles: Formulation Design, In Vitro and In Vivo Studies

Mishra, Amit; Vuddanda, Parameswara Rao; Singh, Sanjay (Hindawi Publishing Corporation, 2014-02-19)

The aim of the present work was to design and develop Praziquantal (PZQ) loaded solid lipid nanoparticles (PZQ-SLN) to improve the oral bioavailability by targeting intestinal lymphatic system. PZQ is practically insoluble ...
Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidovudine in Rats

Purvin, Shah; Vuddanda, Parameswara Rao; Singh, Sanjay Kumar; and et. al. (Hindawi Publishing Corporation, 2014-02-19)

idovudine-loaded solid lipid nanoparticles (AZT-SLNs) and zidovudine in solution were prepared and administered in rats. The aim of this research was to study whether the bioavailability of zidovudine can be improved by ...
Characterization of an ayurvedic drug (Shilajatwadi Lauha)

Gupta, L.N.; Kumar, V.; Kumar, N. (International Journal of Research in Ayurveda and Pharmacy, 2014-08-20)

Shilajatwadi Lauha (SL) is an Ayurvedic Herbo mineral compound formulation used in the treatment of Kshaya and Madhumeha from ancient times. The present study was selected to standardize SL which can be adopted by different ...

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