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Now showing items 1-20 of 178

Development of Buccoadhesive Systems of Pentazocine for Systemic Drug Delivery

Sampathkumar, D.; Thilek Kumar, M.; Balasubramaniam, J.; Pandit, J.K. (Osterreichische Apotheker-Verlagsgesellschaft m.b.H., 200-12-30)

Bucoadhesive patches of Pentazocine (PZ) for unidirectional drug delivery were prepared by casting carboxy methyl cellulose (CMC) with glycerol or propylene glycol and CMC-hydroxy ethyl cellulose (HEC) with glycerol. In ...
Antitumour activity of Rhinacanthone against Dalton's ascitic lymphoma

Thirumurugan, R.S.; Kavimani, S.; Srivastava, R.S. (Pharmaceutical Society of Japan, 2000)

The antitumour activity of Rhinacanthone (3,4-dihydro-3,3-dimethyl-2H-naphtho-[1,2-B] pyran-5,6-dione) has been evaluated against Dalton's ascitic lymphoma (DAL) in Swiss albino mice. A significant enhancement of mean ...
Synthesis and antitumour activity of some aryl semicarbazones

Pandeya, S.N.; Yogeeswari, P.; Sausville, E.A.; Mauger, A.B.; Narayanan, V.L. (Osterreichische Apotheker-Verlagsgesellschaft m.b.H., 2000-12-30)

Various 4-substituted phenyl semicarbazone derivatives were synthesized and evaluated in vitro by NCI in the 3-cell line, one dose primary anticancer assay. Three compounds showed significant activity against breast MCF7 ...
Sodium alginate microspheres of metoprolol tartrate for intranasal systemic delivery: Development and evaluation

Rajinikanth, P.S.; Sankar, C.; Mishra, B. (Taylor and Francis Inc., 2003)

Bioadhesive sodium alginate microspheres of Metoprolol tartrate (MT) for intranasal systemic delivery were prepared to avoid the first-pass effect, as an alternative therapy to injection, and to obtain improved therapeutic ...
Ion-activated in situ gelling systems for sustained ophthalmic delivery of ciprofloxacin hydrochloride

Balasubramaniam, J.; Pandit, J.K. (Taylor and Francis Inc., 2003-09)

The poor bioavailability and therapeutic response exhibited by the conventional ophthalmic solutions due to precorneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled ...
Comparative in vitro and in vivo evaluation of matrix, osmotic matrix, and osmotic pump tablets for controlled delivery of diclofenac sodium

Rani, M.; Mishra, B. (AAPS PharmSci Editorial Office, 2004)

The aim of this investigation was preparation and comparative evaluation of fabricated matrix (FM), osmotic matrix (OM), and osmotic pump (OP) tablets for controlled delivery of diclofenac sodium (DS). All formulations ...
Formulation and biopharmaceutical evaluation of osmotic matrix tablets of diclofenac sodium

Rani, M.; Surana, R.; Sankar, C.; Mishra, B. (2004-07)

The objective of our study was to prepare and evaluate osmotic matrix (OM) tablets of diclofenac sodium (DS). In vitro studies were done on USPXXIV dissolution apparatus II in different release medium. Surface characteristics ...
Cross-linked guar gum hydrogel discs for colon-specific delivery of ibuprofen: Formulation and in vitro evaluation

Das, A.; Wadhwa, S.; Srivastava, A.K. (2006-03-01)

Hydrogel discs of guar gum cross-linked with glutaraldehyde were prepared as vehicles for colon-specific drug delivery. Ibuprofen was chosen as model drug. The discs were evaluated for such parameters as size, shape, weight, ...
Evaluation of Cissampelos pareira against gastric cancer and enzymes associated with carcinogen metabolism

Amresh, G.; Rao, C.V.; Singh, P.N. (2007-10)

The current study is an effort to identify the effect of a hydroalcohol (50% ethanol) extract of roots of Cissampelos pareira (L.) Hirsuta (Menispermaceae) (CPE) in forestomach cancer and on carcinogen metabolizing phase ...
Ethylcellulose inserts of an orphan drug for periodontitis: Preparation, in vitro, and clinical studies

Barat, R.; Srinatha, A.; Pandit, J.K.; Mittal, N.; Anupurba, S. (2007-11)

Ethylcellulose inserts of niridazole fabricated by casting were studied for in vitro release and in vivo clinical effectiveness. The in vitro drug release was steady and sustained for over 7 days and followed diffusion ...
Chitosan inserts for periodontitis: Influence of drug loading, plasticizer and crosslinking on in vitro metronidazole release

Barat, R.; Srinatha, A.; Pandit, J.K.; Anupurba, S.; Mittal, N. (2007-12-01)

Chitosan based metronidazole (MZ) inserts were fabricated by the casting method and characterized with respect to mass and thickness uniformity, metronidazole loading and in vitro metronidazole release kinetics. The ...
Preparation and in vitro characterization of gellan based floating beads of acetohydroxamic acid for eradication of H. pylori

Rajinikanth, P.S.; Mishra, B. (2007-12-01)

Gellan based floating beads of acetohydroxamic acid (AHA) were prepared by the ionotropic gellation method to achieve controlled and sustained drug release for treatment of Helicobacter pylori infection. The prepared beads ...
Design and evaluation of bioadhesive in-situ nasal gel of ketorolac tromethamine

Chelladurai, S.; Mishra, M.; Mishra, B. (2008)

The present study was aimed at developing safe and effective bioadhesive gelling systems of ketorolac tromethamine, a potent non-narcotic analgesic with moderate anti-inflammatory activity for nasal systemic delivery. ...
Concurrent estimation of clopidogrel bisulfate and aspirin in tablets by validated RP-HPLC method

Shrivastava, P.; Basniwal, P.; Jain, D.; Shrivastava, S. (2008-02-01)

A simple, rapid, precise RP-HPLC method was developed for simultaneous estimation of aspirin and clopidogrel bisulphate in tablet dosage form used in the treatment of cardiovascular diseases. To achieve the maximum resolution, ...
Studies on indomethacin intraocular implants using different in vitro release methods

Balasubramaniam, J.; Srinatha, A.; Pandit, J. (2008-02-01)

Intra ocular implants of sodium alginate alone and in combination with hydroxypropylmethylcellulose with or without calcium chloride were formulated with indomethacin as a model drug. The drug release from the implants was ...
Novel immunobiologics for psoriasis

Ghosh, N.; Singh, P.N.; Kumar, V. (2008-05-01)

Psoriasis is one of the most common human skin diseases and is considered to have key genetic contributions. It is characterized by excessive growth and aberrant differentiation of keratinocytes, but is reversible with ...
Preparation and evaluation of buccal bioadhesive films containing clotrimazole

Singh, S.; Jain, S.; Muthu, M.S.; Tiwari, S.; Tilak, R. (2008-06)

Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms. The aim of present study was to prepare and evaluate buccal ...
Formulation and evaluation of clarithromycin microspheres for eradication of Helicobacter pylori

Rajinikanth, P.S.; Karunagaran, L.N.; Balasubramaniam, J. (2008-12)

The objective of the study was to develop a stomach-specific drug delivery system for controlled release of clarithromycin for eradication of Helicobacter pylori (H. pylori). Floating-bioadhesive microspheres of clarithromycin ...
Fabrication and evaluation of taste masked resinate of risperidone and its orally disintegrating tablets

Shukla, D.; Chakraborty, S.; Singh, S.; Mishra, B. (2009)

The present investigation was undertaken to design a simple, rapid, cost effective and highly efficient process to fabricate a tasteless complex of risperidone using ion exchange resin (IER), evaluate the molecular properties ...
Development and biopharmaceutical evaluation of extended release formulation of tramadol hydrochloride based on osmotic technology

Kumar, P.; Singh, S.; Mishra, B. (2009-03-01)

Extended release formulation of tramadol hydrochloride (TRH) based on osmotic technology was developed and evaluated. Target release profile was selected and different variables were optimized to achieve it. Formulation ...

Now showing items 1-20 of 178

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