Department of Pharmaceutical Engineering: Recent submissions

Now showing items 141-160 of 178

Pharmacognostical and phytochemical standardization of Houttuynia cordata Thunb

Kumar, Manish; Prasad, Satyendra K.; Laloo, Damiki; and et. al. (EManuscript Services, 2014-02)

Aim: Houttuynia cordata Thunb. (Saururaceae) is one of the perennial herb indigenous to North-East India and China. Despite the popular utilization of this herb as medicine, still no study has been reported so far regarding ...
DNA Fingerprinting Profile and Quality Control Standardization of Folklore Medicinal Plant Exacum lawii

Sharma, Sonam; Hemalatha, Siva (EManuscript Services, 2017-08-22)

Context and Aim: Exacum lawii (Gentianaceae) is bitter folk medicinal herb. The study deals with molecular investigation by DNA fingerprinting profile of Exacum lawii, quality control and phytochemical standardization of ...
Diazepam Potentiates the Antidiabetic, Antistress and Anxiolytic Activities of Metformin in Type-2 Diabetes Mellitus with Cooccurring Stress in Experimental Animals

Garabadu, Debapriya; Krishnamurthy, Sairam (Hindawi Publishing Corporation, 2014-06-04)

Psychological stress is considered as one of the limiting factors in the management of type-2 diabetes mellitus (T2DM). Therefore, the basic objective of the present study was to evaluate the antidiabetic effect of metformin, ...
Antihyperglycemic Activity of Houttuynia cordata Thunb. in Streptozotocin-Induced Diabetic Rats

Kumar, Manish; Prasad, Satyendra K.; Krishnamurthy, Sairam; and et. al. (Hindawi Publishing Corporation, 2014-02-24)

Present study is an attempt to investigate plausible mechanism involved behind antidiabetic activity of standardized Houttuynia cordata Thunb. extract in streptozotocin-induced diabetic rats. The plant is used as a medicinal ...
Revealing facts behind spray dried solid dispersion technology used for solubility enhancement

Patel, Bhavesh B.; Patel, Jayvadan K.; Chakraborty, Subhashis; Shukla, Dali (Elsevier, 2013-12-23)

Poor solubility and bioavailability of an existing or newly synthesized drug always pose challenge in the development of efficient pharmaceutical formulation. Numerous technologies can be used to improve the solubility and ...
Formulation and optimization of itraconazole polymeric lipid hybrid nanoparticles (Lipomer) using box behnken design

Gajra, Balaram; Dalwadi, Chintan; Patel, Ravi (BioMed Central Ltd., 2015)

Background: The objective of the study was to formulate and to investigate the combined influence of 3 independent variables in the optimization of Polymeric lipid hybrid nanoparticles (PLHNs) (Lipomer) containing hydrophobic ...
Adaptogenic potential of andrographolide: An active principle of the king of bitters (Andrographis paniculata)

Thakur, Ajit Kumar; Chatterjee, Shyam Sunder; Kumar, Vikas (National Taiwan University, 2014-12-19)

Andrographolide is a major bioactive secondary plant metabolite isolated Andrographis paniculata (Burm. F.)Wall. Ex. Nees. (chuan xin lian), awell-known traditionally used medicinal herb. The aim of the study was to ...
Assessing the viability of Soluplus® self-assembled nanocolloids for sustained delivery of highly hydrophobic lapatinib (anticancer agent): Optimisation and in-vitro characterisation

Bonde, Gunjan Vasant; Ajmal, Gufran; Yadav, Sarita Kumari; Mittal, Pooja; Singh, Juhi; Bakde, Bharati V.; Mishra, Brahmeshwar (Elsevier B.V., 2019-10-29)

Nanocolloids are considered ideal carriers for hydrophobic drugs owing to their core–shell structure. Lapatinib is a potential anti-cancer agent, but its clinical use is limited because of its poor aqueous solubility, thus ...
Design and comparative in-vitro and in-vivo evaluation of starch-acrylate graft copolymer based salbutamol sulphate sustained release tablets

Kumar, Pankaj; Ganure, Ashok Laxmanrao; Subudhi, Bharat Bhushan; and et al (Shenyang Pharmaceutical University, 2014-12-22)

The present work deals with the development of controlled release tablets of salbutamol sulphate (SS) using graft copolymers of methyl methacrylate (St-g-PMMA and Ast-g-PMMA) on starch and acetylated starch. Formulations ...
Antiulcer activity of the most active sub-fraction of methanolic leaf extract of Buchanania Lanzan Spreng

Rai, Uddipak; Pattnaik, Ashok Kumar; Singh, Sanjay (Innovare Academics Sciences Pvt. Ltd, 2016-07-22)

Objective: To evaluate the antiulcer activity of the most active sub-fraction of Buchanania lanzan Spreng. leaves methanolic extract (BLE). Methods: The antioxidant activity of BLE fractions and sub-fractions has been ...
Quality Control standardization of Wild Himalayan Pear: Pyrus pashia

Hemalatha, Siva; Sharma, Priyanka; Prasad, Satyendra Kuldip (EManuscript Services, 2016-12)

Introduction: To establish the pharmacognostical and phytochemical standardization parameters of Pyrus pashia fruits in order to ensure quality and safety of this traditionally acclaimed medicinal tree. Methods: The fresh ...
Drug nanocrystals

Srivalli, Kale Mohana Raghava; Mishra, Brahmeshwar (Elsevier B.V., 2014-05-09)

Drug nanocrystals comprise unique drug delivery platforms playing a significantly important and distinctive role in drug delivery and as such, the industry and academia are spending a lot of their time and money in developing ...
Phytochemical standardization, antioxidant, and antibacterial evaluations of Leea macrophylla

Joshi, Apurva; Prasad, Satyendra K.; Joshi, Vinod Kumar; Hemalatha, Siva (Elsevier Taiwan LLC, 2016-01-13)

In Ayurveda, Leea macrophylla Roxb. ex Hornem. (Leeaceae) is indicated in worm infestation, dermatopathies, wounds, inflammation, and in symptoms of diabetes. The present study aims to determine the antioxidant and ...
Improved Aqueous Solubility and Antihypercholesterolemic Activity of Ezetimibe on Formulating with Hydroxypropyl-β-Cyclodextrin and Hydrophilic Auxiliary Substances

Srivalli, Kale Mohana Raghava; Mishra, Brahmeshwar (Springer New York LLC, 2015-06-16)

The purpose of this study was to improve the aqueous solubility, dissolution, and pharmacodynamic properties of a BCS class II drug, ezetimibe (Eze) by preparing ternary cyclodextrin complex systems. We investigated the ...
A facile microwave assisted one pot synthesis of novel xanthene derivatives as potential anti-inflammatory and analgesic agents

Banerjee, Anupam G.; Kothapalli, Lata P.; Sharma, Piyoosh A.; and et al (Elsevier B.V., 2011-06-15)

Microwave assisted irradiation of resorcinol and substituted aryl aldehydes using sulfamic acid as catalyst afforded novel 9-aryl-9H-xanthene-3,6-diol derivatives (1a–f) in good yields. The newly synthesized compounds which ...
Preventive potentials of piperlongumine and a Piper longum extract against stress responses and pain

Yadav, Vaishali; Chatterjee, Shyam Sunder; Majeed, Muhammed; Kumar, Vikas (National Taiwan University, 2015-12-11)

Aim To compare stress resistance increasing and analgesic activities of piperlongumine and a methanolic Piper longum fruit extract (PLE). Methods Efficacies of a single and repeated daily oral doses (1–256 mg/kg/day) of ...
Natural polymers composed mucoadhesive interpenetrating buoyant hydrogel beads of capecitabine: Development, characterization and in vivo scintigraphy

Upadhyay, Mansi; Vardhan, Harsh; Mishra, Brahmeshwar (Editions de Sante, 2020-02)

The present research deals with the optimization and preparation of aluminium ion cross-linked buoyant interpenetrating polymeric network (IPN) microbeads (MBs) of locust bean gum (LBG) and sodium alginate(NaAlg) carrying ...
In Vitro Study on Glucose Utilization Capacity of Bioactive Fractions of Houttuynia cordata in Isolated Rat Hemidiaphragm and Its Major Phytoconstituent

Kumar, Manish; Prasad, Satyendra K.; Hemalatha, Siva (Hindawi Limited, 2015-12-28)

Objective. The whole plant of Houttuynia cordata has been reported to have potent antihyperglycemic activity. Therefore, the present study was undertaken to investigate the glucose utilization capacity of bioactive fractions ...
Green synthesis of silver nanoparticles using aqueous leaf extract of Premna integrifolia (L.) rich in polyphenols and evaluation of their antioxidant, antibacterial and cytotoxic activity

Singh, Chandrashekhar; Kumar, Jitendra; Kumar, Pradeep; Chauhan, Brijesh Singh; Tiwari, Kavindra Nath; Mishra, Sunil Kumar; Srikrishna, S.; Saini, Rajesh; Nath, Gopal; Singh, Jasmeet (Taylor and Francis Ltd., 2019-02-12)

Premna integrifolia L. is widely distributed in tropical and subtropical regions. In the present study, green silver nanoparticles were synthesized efficiently after mixing 1 mmol/L AgNO3 and 4% aqueous leaf extract at ...
Design, Synthesis and Biological Profiling of Novel Phenothiazine Derivatives as Potent Antitubercular Agents

Sellamuthu, Satheeshkumar; Kumar, Ashok; Nath, Gopal; Singh, Sushil Kumar (Bentham Science Publishers B.V., 2018-07-11)

Background: Neuroleptic phenothiazines have been reported for antitubercular activity, but the unwanted side effect (antipsychotic activity) restricted their use as antitubercular drugs. Objective: The study aimed to carry ...

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