Department of Pharmaceutical Engineering: Recent submissions

Now showing items 101-120 of 178

Evaluation of Cissampelos pareira against gastric cancer and enzymes associated with carcinogen metabolism

Amresh, G.; Rao, C.V.; Singh, P.N. (2007-10)

The current study is an effort to identify the effect of a hydroalcohol (50% ethanol) extract of roots of Cissampelos pareira (L.) Hirsuta (Menispermaceae) (CPE) in forestomach cancer and on carcinogen metabolizing phase ...
Ethylcellulose inserts of an orphan drug for periodontitis: Preparation, in vitro, and clinical studies

Barat, R.; Srinatha, A.; Pandit, J.K.; Mittal, N.; Anupurba, S. (2007-11)

Ethylcellulose inserts of niridazole fabricated by casting were studied for in vitro release and in vivo clinical effectiveness. The in vitro drug release was steady and sustained for over 7 days and followed diffusion ...
Chitosan inserts for periodontitis: Influence of drug loading, plasticizer and crosslinking on in vitro metronidazole release

Barat, R.; Srinatha, A.; Pandit, J.K.; Anupurba, S.; Mittal, N. (2007-12-01)

Chitosan based metronidazole (MZ) inserts were fabricated by the casting method and characterized with respect to mass and thickness uniformity, metronidazole loading and in vitro metronidazole release kinetics. The ...
Preparation and in vitro characterization of gellan based floating beads of acetohydroxamic acid for eradication of H. pylori

Rajinikanth, P.S.; Mishra, B. (2007-12-01)

Gellan based floating beads of acetohydroxamic acid (AHA) were prepared by the ionotropic gellation method to achieve controlled and sustained drug release for treatment of Helicobacter pylori infection. The prepared beads ...
Cross-linked guar gum hydrogel discs for colon-specific delivery of ibuprofen: Formulation and in vitro evaluation

Das, A.; Wadhwa, S.; Srivastava, A.K. (2006-03-01)

Hydrogel discs of guar gum cross-linked with glutaraldehyde were prepared as vehicles for colon-specific drug delivery. Ibuprofen was chosen as model drug. The discs were evaluated for such parameters as size, shape, weight, ...
Comparative in vitro and in vivo evaluation of matrix, osmotic matrix, and osmotic pump tablets for controlled delivery of diclofenac sodium

Rani, M.; Mishra, B. (AAPS PharmSci Editorial Office, 2004)

The aim of this investigation was preparation and comparative evaluation of fabricated matrix (FM), osmotic matrix (OM), and osmotic pump (OP) tablets for controlled delivery of diclofenac sodium (DS). All formulations ...
Formulation and biopharmaceutical evaluation of osmotic matrix tablets of diclofenac sodium

Rani, M.; Surana, R.; Sankar, C.; Mishra, B. (2004-07)

The objective of our study was to prepare and evaluate osmotic matrix (OM) tablets of diclofenac sodium (DS). In vitro studies were done on USPXXIV dissolution apparatus II in different release medium. Surface characteristics ...
Development of Buccoadhesive Systems of Pentazocine for Systemic Drug Delivery

Sampathkumar, D.; Thilek Kumar, M.; Balasubramaniam, J.; Pandit, J.K. (Osterreichische Apotheker-Verlagsgesellschaft m.b.H., 200-12-30)

Bucoadhesive patches of Pentazocine (PZ) for unidirectional drug delivery were prepared by casting carboxy methyl cellulose (CMC) with glycerol or propylene glycol and CMC-hydroxy ethyl cellulose (HEC) with glycerol. In ...
Antitumour activity of Rhinacanthone against Dalton's ascitic lymphoma

Thirumurugan, R.S.; Kavimani, S.; Srivastava, R.S. (Pharmaceutical Society of Japan, 2000)

The antitumour activity of Rhinacanthone (3,4-dihydro-3,3-dimethyl-2H-naphtho-[1,2-B] pyran-5,6-dione) has been evaluated against Dalton's ascitic lymphoma (DAL) in Swiss albino mice. A significant enhancement of mean ...
Synthesis and antitumour activity of some aryl semicarbazones

Pandeya, S.N.; Yogeeswari, P.; Sausville, E.A.; Mauger, A.B.; Narayanan, V.L. (Osterreichische Apotheker-Verlagsgesellschaft m.b.H., 2000-12-30)

Various 4-substituted phenyl semicarbazone derivatives were synthesized and evaluated in vitro by NCI in the 3-cell line, one dose primary anticancer assay. Three compounds showed significant activity against breast MCF7 ...
Sodium alginate microspheres of metoprolol tartrate for intranasal systemic delivery: Development and evaluation

Rajinikanth, P.S.; Sankar, C.; Mishra, B. (Taylor and Francis Inc., 2003)

Bioadhesive sodium alginate microspheres of Metoprolol tartrate (MT) for intranasal systemic delivery were prepared to avoid the first-pass effect, as an alternative therapy to injection, and to obtain improved therapeutic ...
Ion-activated in situ gelling systems for sustained ophthalmic delivery of ciprofloxacin hydrochloride

Balasubramaniam, J.; Pandit, J.K. (Taylor and Francis Inc., 2003-09)

The poor bioavailability and therapeutic response exhibited by the conventional ophthalmic solutions due to precorneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled ...
Design, Synthesis, and Biological Evaluation of Multitargeted N-Benzylpiperidine Analogs for the Treatment of Alzheimer’s Disease

Sharma, Piyoosh (IIT (BHU) varanasi, 2019)

Alzheimer’s disease (AD) is a multifactorial disorder, and several pathophysiological mechanisms are involved in its progression and development. Current therapeutic regimens only provide symptomatic relief and are ...
Nanotheranostics: Emerging strategies for early diagnosis and therapy of brain cancer

Sonali; Viswanadh, M.K.; Singh, R.P.; Agrawal, P.; Mehata, A.K.; Pawde, D.M.; Narendra; Sonkar, R.; Muthu, M.S. (Ivyspring International Publisher, 2018)

Nanotheranostics have demonstrated the development of advanced platforms that can diagnose brain cancer at early stages, initiate first-line therapy, monitor it, and if needed, rapidly start subsequent treatments. In brain ...
AMPK Contributes to Cardioprotective Effects of Pterostilbene Against Myocardial Ischemia- Reperfusion Injury in Diabetic Rats by Suppressing Cardiac Oxidative Stress and Apoptosis

Kosuru, R.; Cai, Y.; Kandula, V.; Yan, D.; Wang, C.; Zheng, H.; Li, Y.; Irwin, M.G.; Singh, S.; Xia, Z. (S. Karger AG, 2018-05-01)

Background/Aims: Pterostilbene (PT) exerts antidiabetic effects by decreasing blood glucose and modulating lipid metabolism and has been shown to attenuate myocardial ischemia-reperfusion (IR) injury in non-diabetic subjects. ...
Targeted bioadhesive nanomedicine: An effective approach for synergistic drug delivery to cancers

Viswanadh, M.K.; Muthu, M.S. (Future Medicine Ltd., 2018-06)
Implication of linker length on cell cytotoxicity, pharmacokinetic and toxicity profile of gemcitabine-docetaxel combinatorial dual drug conjugate

Kushwah, V.; Katiyar, S.S.; Agrawal, A.K.; Saraf, I.; Singh, I.P.; Lamprou, D.A.; Gupta, R.C. (Elsevier B.V., 2018-09-05)

The present study investigates effect of linkers [zero length (without linker), short length linker (glycine and lysine) and long length linker (PEG1000, PEG2000 and PEG3500)] on pharmacokinetics and toxicity of docetaxel ...
What are the unexplored facts about nanomicelles formed from docetaxel clinical injection?

Vikas; Viswanadh, M.K.; Priya, V.; Mehata, A.K.; Muthus, M.S. (Future Medicine Ltd., 2019)
Triacetyl resveratrol upregulates miRNA-200 and suppresses the Shh pathway in pancreatic cancer: A potential therapeutic agent

Fu, J.; Srivastava, A.; Srivastava, S.K.; Srivastava, R.K.; Shankar, S. (Spandidos Publications, 2019-04)

Trans-3,4',5-trihydroxystilbene (resveratrol) is a naturally occurring polyphenolic phytoalexin with marked anticancer activities, and is mainly found in grapes, berries and peanuts. However, due to a low bioavailability, ...
Sars-cov-2 host entry and replication inhibitors from Indian ginseng: an in-silico approach

Chikhale, R.V.; Gurav, S.S.; Patil, R.B.; Sinha, S.K.; Prasad, S.K.; Shakya, A.; Srivastava, S.K.; Gurav, N.S.; Prasad, R.S. (Taylor and Francis Ltd., 2020)

COVID-19 has ravaged the world and is the greatest of pandemics in modern human history, in the absence of treatment or vaccine, the mortality and morbidity rates are very high. The present investigation identifies potential ...

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