Department of Pharmaceutical Engineering: Recent submissions

Now showing items 61-80 of 178

Efficient Catalytic Degradation of Selected Toxic Dyes by Green Biosynthesized Silver Nanoparticles Using Aqueous Leaf Extract of Cestrum nocturnum L.

Kumar, Pradeep; Dixit, Jyoti; Singh, Amit Kumar; Rajput, Vishnu D.; Verma, Pooja; Tiwari, Kavindra Nath; Mishra, Sunil Kumar; Minkina, Tatiana; Mandzhieva, Saglara (MDPI, 2022-11)

In the present study, the catalytic degradation of selected toxic dyes (methylene blue, 4-nitrophenol, 4-nitroaniline, and congo red) using biosynthesized green silver nanoparticles (AgNPs) of Cestrum nocturnum L. was ...
Intranasally Co-administered Berberine and Curcumin Loaded in Transfersomal Vesicles Improved Inhibition of Amyloid Formation and BACE-1

Mishra, Gaurav; Awasthi, Rajendra; Singh, Anurag Kumar; Singh, Snigdha; Mishra, Sunil Kumar; Singh, Santosh Kumar; Nandi, Manmath K. (American Chemical Society, 2022-11)

Selective permeability of the blood-brain barrier restricts the treatment efficacy of neurologic diseases. Berberine (BBR) and curcumin (CUR)-loaded transferosomes (TRANS) were prepared for the effective management of ...
Molecular and pharmacological aspects of piperine as a potential molecule for disease prevention and management: evidence from clinical trials

Tripathi, Amit Kumar; Ray, Anup Kumar; Mishra, Sunil Kumar (Springer Science and Business Media Deutschland GmbH, 2022-12)

Piperine is a type of amide alkaloid that exhibits pleiotropic properties like antioxidant, anticancer, anti-inflammatory, antihypertensive, hepatoprotective, neuroprotective and enhancing bioavailability and fertility-related ...
Decrypting the cellular and molecular intricacies associated with COVID-19-induced chronic pain

Rani, Mousmi; Uniyal, Ankit; Akhilesh; Tiwari, Vinod (Springer, 2022-12)

Pain is one of the clinical manifestations that can vary from mild to severe symptoms in COVID-19 patients. Pain symptoms can be initiated by direct viral damage to the tissue or by indirect tissue injury followed by ...
Identification and validation of core genes as promising diagnostic signature in hepatocellular carcinoma based on integrated bioinformatics approach

Kumar, Pradeep; Singh, Amit Kumar; Tiwari, Kavindra Nath; Mishra, Sunil Kumar; Rajput, Vishnu D.; Minkina, Tatiana; Cavalu, Simona; Pop, Ovidiu (Nature Research, 2022-12)

The primary objective of this investigation was to determine the hub genes of hepatocellular carcinoma (HCC) through an in silico approach. In the current context of the increased incidence of liver cancers, this approach ...
Exploration of Novel Lichen Compounds as Inhibitors of SARS-CoV-2 Mpro: Ligand-Based Design, Molecular Dynamics, and ADMET Analyses

Gupta, Amit; Sahu, Niharika; Singh, Ashish P; Singh, Vinay Kumar; Singh, Suresh C; Upadhye, Vijay J; Mathew, Alen T; Kumar, Rajnish; Sinha, Rajeshwar P. (Springer, 2022-12)

In the year 2019–2020, the whole world witnessed the spread of a disease called COVID19 caused by SARS-CoV-2. A number of efective drugs and vaccine has been formulated to combat this outbreak. For the development of ...
Tinospora cordifolia Leaves Derived Carbon dots for Cancer Cell Bioimaging Free radical Scavenging, and Fe3+ Sensing Applications

Mohapatra, Debadatta; Pratap, Ravi; Pandey, Vivek; Dubey, Pawan K.; Agrawal, Ashish K.; Parmar, Avanish S.; Sahu, Alakh N. (Springer, 2022-01)

Herein, we report the fabrication of Tinospora cordifolia leaves-derived carbon dots(TCLCDs) from aqueous extract of leaves as carbon source via simple,environmentally friendly, hydrothermal carbonization (HTC) technique. ...
Targeting SARS-CoV-2 main protease: structure based virtual screening, in silico ADMET studies and molecular dynamics simulation for identification of potential inhibitors

Uniyal, Ankit; Mahapatra, Manoj Kumar; Tiwari, Vinod; Sandhir, Rajat; Kumar, Rajnish (Taylor and Francis Ltd., 2022-05)

COVID-19 pandemic has created a healthcare crisis across the world and has put human life under life-threatening circumstances. The recent discovery of the crystallized structure of the main protease (Mpro) from SARS-CoV-2 ...
A review article on neuroprotective, immunomodulatory, and anti-inflammatory role of vitamin-D3 in elderly COVID-19 patients

Tripathi, Amit Kumar; Mishra, Sunil Kumar (Springer Science and Business Media Deutschland GmbH, 2023-12)

Vitamin D3 is a secosteroid, broad-spectrum immunomodulatory, antioxidant, and anti-inflammatory hormone produced either by the internal subcutaneous pathway in the presence of ultraviolet B (UVB) rays or by the external ...
A review article on neuroprotective, immunomodulatory, and anti-inflammatory role of vitamin-D3 in elderly COVID-19 patients

Tripathi, Amit Kumar; Mishra, Sunil Kumarb (Springer Science and Business Media Deutschland GmbH, 2023-12)

Vitamin D3 is a secosteroid, broad-spectrum immunomodulatory, antioxidant, and anti-inflammatory hormone produced either by the internal subcutaneous pathway in the presence of ultraviolet B (UVB) rays or by the external ...
Elemental Composition and Freezing Tolerance in High Arctic Fishes and Invertebrates

Singh, Shiv Mohan; Tsuji, Masaharu; Singh, Purnima; Mulik, Ravindra Uttam (MDPI, 2022-09)

The elemental composition in different Arctic fishes and invertebrates was investigated using Inductively Coupled Plasma Mass Spectrophotometer (ICPMS). Nineteen elements such as Arsenic (As), Barium (Ba), Bismuth (Bi), ...
Benzothiazole based fluorescent probes for the detection of biomolecules, physiological conditions, and ions responsible for diseases

Das, S; Indurthi, H K; Asati, P; Saha, P; Sharma, D K (Elsevier Ltd, 2021-12-31)

Benzothiazole-based fluorescent probes are formed by decorating benzothiazole fluorophore with a small chemical fragment capable of detecting a particular biological species or physiological condition. Due to a variety of ...
Rifabutin loaded floating gellan gum beads: In vitro and in vivo evaluation

Verma, A.; Pandit, J.K. (Academic Journals, 2011-05)

Rifabutin loaded floating gellan gum beads were prepared by ionotropic gelation in acidic medium. Buoyancy to the beads was attributed to the use of gas-generating agent, which produced an extremely porous internal structure ...
Formulation of fast-release gastroretentive solid dispersion of glibenclamide with gelucire 50/13

Upadhyay, P.; Pandit, J.K. (University of Benin, 2012-06)

Purpose: Fast-release gastroretentive solid dispersions of glibenclamide using gelucire were prepared to achieve improved bioavailability. Methods: Hot melt granulation technique was adopted to prepare solid dispersions ...
A review on pharmacological and analytical aspects of diosgenin: a concise report

Patel, K.; Gadewar, M.; Tahilyani, V.; Patel, D.K. (Springer, 2012-04-01)

Diosgenin is a steroidal sapogenin found in plants such as Dioscorea nipponoca, Solanum incanum, Solanum xanthocarpum and Trigonella foenum graecum. Diosgenin, biologically active phytochemicals have been used for the ...
Low molecular mass chitosan as carrier for a hydrodynamically balanced system for sustained delivery of ciprofloxacin hydrochloride

Verma, A.; Bansal, A.; Ghosh, A.; Pandit, J. (2012-06-01)

Chitosan has become a focus of major interest in recent years due to its excellent biocompatibility, biodegradability and non-toxicity. Although this material has already been extensively investigated in the design of ...
Bioadhesive microspheres for bioavailability enhancement of raloxifene hydrochloride

Jha, R.K.; Tiwari, S.; Mishra, B. (Springer New York LLC, 2011-06)

Raloxifene hydrochloride (R-HCl), a BCS class II drug, remains a mainstay in the prevention and pharmacologic therapy of osteoporosis. Its absolute bioavailability, however, is 2% due to poor solubility and extensive first ...
Phytochemical and pharmacological evaluation of prop roots of Pandanus fascicularis Lam

Rajeswari, J.; Kesavan, K.; Jayakar, B. (2011-08)

Objective: To evaluate the anti-inflammatory and analgesic activities of the ethanol and aqueous extracts of prop roots of Pandanus fascicularis (P. fascicularis) Lam (pandanaceae). And provide experimental evidence for ...
Fabrication of lomustine loaded chitosan nanoparticles by spray drying and in vitro cytostatic activity on human lung cancer cell line L132

Mehrotra, A.; Nagarwal, R.C.; Pandit, J.K. (2010-11)

This study was aimed to develop lomustine loaded chitosan nanoparticles using a homogenization and spray drying technique. Effect of crosslinking agents (sodium tripolyphosphate (TPP), and sodium hexametaphosphate (HMP)) ...
Biodegradable microparticulate drug delivery system of diltiazem HCl

Guata, M.K.; Prakash, D.; Mishra, B. (2012-10)

The efficacy of a drug in a specific application requires the maintenance of appropriate drug blood level concentration during a prolonged period of time. Controlled release delivery is available for many routes of ...

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