Department of Pharmaceutical Engineering: Recent submissions

Now showing items 41-60 of 178

Deep learning tools for advancing drug discovery and development

Nag, Sagorika; Baidya, Anurag T. K.; Mathew, Alen T.; Das, Bhanuranjan; Devi, Bharti; Kumar, Rajnish; Mandal, Abhimanyu (Springer Science and Business Media Deutschland GmbH, 2022-05)

A few decades ago, drug discovery and development were limited to a bunch of medicinal chemists working in a lab with enormous amount of testing, validations, and synthetic procedures, all contributing to considerable ...
Emergence of Nanotechnology as a Powerful Cavalry against Triple-Negative Breast Cancer (TNBC)

Chaudhuri, Aiswarya; Kumar, Dulla Naveen; Dehari, Deepa; Singh, Sanjay; Kumar, Pradeep; Bolla, Pradeep Kumar; Kumar, Dinesh; Agrawal, Ashish Kumar (MDPI, 2022-05)

Triplenegative breast cancer (TNBC) is considered one of the unmanageable types of breast cancer, involving devoid of estrogen, progesterone, and human epidermal growth factor receptor 2 (HER 2) receptors. Due to their ...
Germplasm conservation of economically important medicinal plant Nyctanthes arbor-tristis L. through encapsulation technique and maintenance under slow growth condition

Mishra, Awadhesh Kumar; Tiwari, Kavindra Nath; Mishra, Pallavi; Mishra, Sunil Kumar; Tiwari, Shailesh Kumar (Springer Science and Business Media B.V., 2022-05)

An efficient encapsulation and slow growth conservation protocol was developed for Nyctanthes arbor-tristis L. an antiviral medicinal plant of the family Oleaceae. A gel matrix with 3% sodium alginate and 100 mM calcium ...
Acute and subacute toxicity study of ethanolic extract of Calotropis procera (Aiton) Dryand flower in Swiss albino mice

Kumar, Ashutosh; Kumar, Brijesh; Kumar, Rajesh; Kumar, Ajay; Singh, Manish; Tiwari, Vinod; Trigunayat, Anshuman; Paul, Paramita; Singh, Pratistha (Elsevier B.V., 2022-05)

Calotropis procera is a large shrub which consists many medicinal properties, used in treatment of snake bite, sinus fistula, rheumatism, mumps, burn injuries, inflammation and jaundice traditionally. All the parts of ...
Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting β-catenin/TCF4 signaling pathway

Neogi, Kaushik; Murumkar, Prashant R.; Sharma, Priyanshu; Yadav, Poonam; Tewari, Mallika; Karunagaran, Devarajan; Nayak, Prasanta Kumar; Yadav, Mange Ram (Neoplasia Press, Inc., 2022-05)

Overactivation of Wnt/β-catenin signaling by accumulated β-catenin in the nucleus has been shown to play a crucial role in the etiology of cancer. Interaction of β-catenin with Transcription factor 4 (TCF4) is a key step ...
Allosteric Binding Sites of Aβ Peptides on the Acetylcholine Synthesizing Enzyme ChAT as Deduced by In Silico Molecular Modeling

Baidya, Anurag T. K.; Kumar, Amit; Kumar, Rajnish; Darreh-Shori, Taher (MDPI, 2022-06-01)

The native function of amyloid-β (Aβ) peptides is still unexplored. However, several recent reports suggest a prominent role of Aβ peptides in acetylcholine homeostasis. To clarify this role of Aβ, we have reported that ...
Continuous artificial light potentially disrupts central and peripheral reproductive clocks leading to altered uterine physiology and reduced pregnancy success in albino mice

Das, Megha; Minocha, Tarun; Kumar, Dhanananajay; Yadav, Sanjeev Kumar; Haldar, Chandana (Springer Nature, 2022-07)

Aims: The mechanism behind clock coordination in female reproductive disorders is poorly understood despite the known importance of coordinated and synchronized timing of central and clocks in reproductive organs. We ...
Therapeutic approaches for the treatment of head and neck squamous cell carcinoma–An update on clinical trials

Goel, Bharat; Tiwari, Anoop Kumar; Pandey, Rajeev Kumar; Singh, Akhand Pratap; Kumar, Sujeet; Sinha, Abhishek; Jain, Shreyans K.; Khattri, Arun (Neoplasia Press, Inc., 2022-07)

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin cancer with a tobacco consumption and infection with high-risk human papillomavirus (HPV) being major risk factors. Despite advances in numerous ...
Potential of histone deacetylase inhibitors in the control and regulation of prostate, breast and ovarian cancer

Pramanik, Siddhartha Das; Kumar Halder, Amit; Mukherjee, Ushmita; Kumar, Dharmendra; Dey, Yadu Nandan; Mogana R. (Frontiers Media S.A., 2022-08)

Histone deacetylases (HDACs) are enzymes that play a role in chromatin remodeling and epigenetics. They belong to a specific category of enzymes that eliminate the acetyl part of the histones’ -N-acetyl lysine, causing the ...
Antiproliferative Potential of Gloriosine: A Lead for Anticancer Drug Development

Goel, Bharat; Dey, Biswajit; Chatterjee, Essha; Tripathi, Nancy; Bhardwaj, Nivedita; Kumar, Sanjay; Guru, Santosh Kumar; Jain, Shreyans K. (American Chemical Society, 2022-08)

Gloriosine, a colchicine-like natural product, is widely obtained from Gloriosa superba roots. Despite having remarkable anticancer potential, colchicine could not pave its way to the clinic, while gloriosine is yet to be ...
Combination Therapy Comprising Paclitaxel and 5-Fluorouracil by Using Folic Acid Functionalized Bovine Milk Exosomes Improves the Therapeutic Efficacy against Breast Cancer

Kumar, Dulla Naveen; Chaudhuri, Aiswarya; Dehari, Deepa; Shekher, Anusmita; Gupta, Subash C.; Majumdar, Shreyasi; Krishnamurthy, Sairam; Singh, Sanjay; Kumar, Dinesh; Agrawal, Ashish Kumar (MDPI, 2022-08)

Paclitaxel (PAC) has been approved by FDA for clinical use (Taxol®), yet dose-dependent severe toxicity due to the adjuvant Cremophor EL® in combination with ethanol is a major drawback. The drawbacks of the current therapy ...
Low expression of TMPRSS2–a SARS-CoV-2 internalization protease–associates with basal subtype of head and neck squamous cell carcinoma

Tiwari, Jayesh; Tripathi, Nancy; Srivastava, Ravi Shanker; Kumar, Sujeet; Singh, Sanjay; Jain, Shreyans; Khattri, Arun (Neoplasia Press, Inc., 2022-08)

SARS-CoV-2 is a single-stranded RNA virus that has caused the ongoing COVID-19 pandemic. ACE2 and other genes utilized by SARS-CoV-2 to enter human cells have been shown to express in Head and Neck Squamous Cell Carcinoma ...
Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors

Shrivastava, Sushant Kumar; Sinha, Ojaswi; Kumar, Munish; Waiker, Digambar Kumar; Verma, Akash; Tripathi, Prabhash Nath; Bhardwaj, Bhagwati; Saraf, Poorvi (Springer, 2022-09)

In our present work, some novel substituted 4-phenyl-5-vinylpyrrolidin-2-one derivatives were designed, synthesized, and evaluated for their γ-aminobutyric acid-aminotransferase (GABA-AT) inhibition and in-vivo anticonvulsant ...
Exploring the Potential of Chemical Inhibitors for Targeting Post-translational Glycosylation of Coronavirus (SARS-CoV-2)

Tripathi, Nancy; Goel, Bharat; Bhardwaj, Nivedita; Vishwakarma, Ram; Jain, Shreyans K. (American Chemical Society, 2022-08)

The Spike (S) protein of SARS-CoV-2 expressed on the viral cell surface is of particular importance as it facilitates viral entry into the host cells. The S protein is heavily glycosylated with 22 N-glycosylation sites and ...
Lipid-Based Nanoparticles as a Pivotal Delivery Approach in Triple Negative Breast Cancer (TNBC) Therapy

Chaudhuri, Aiswarya; Kumar, Dulla Naveen; Shaik, Rasheed A.; Eid, Basma G.; Abdel-Naim, Ashraf B.; Md, Shadab; Ahmad, Aftab; Agrawal, Ashish Kumar (MDPI, 2022-09)

Triple-negative breast cancer is considered the most aggressive type of breast cancer among women and the lack of expressed receptors has made treatment options substantially limited. Recently, various types of nanoparticles ...
Mitochondrial targeting theranostic nanomedicine and molecular biomarkers for efficient cancer diagnosis and therapy

Rout, Susanta Kumar; Priya, Vishnu; Setia, Aseem; Mehata, Abhishesh Kumar; Mohan, Syam; Albratty, Mohammed; Najmi, Asim; Meraya, Abdulkarim M; Makeen, Hafiz A.; Tambuwala, Murtaza M; Muthu, Madaswamy S. (Elsevier Masson s.r.l., 2022-09)

Mitochondria play a crucial part in the cell's ability to adapt to the changing microenvironments and their dysfunction is associated with an extensive array of illnesses, including cancer. Mitochondrial dysfunction has ...
Correction to: Multifactorial pathways in burn injury-induced chronic pain: novel targets and their pharmacological modulation (Molecular Biology Reports, (2022), 10.1007/s11033-022-07748-9)

Roy, Tapas Kumar; Uniyal, Ankit; Akhilesh; Tiwari, Vinod (Springer Science and Business Media B.V., 2022-10)

Burn injuries are among the highly prevalent medical conditions worldwide that occur mainly in children, military veterans and victims of fire accidents. It is one of the leading causes of temporary as well as permanent ...
Computational exploration of the dual role of the phytochemical fortunellin: Antiviral activities against SARS-CoV-2 and immunomodulatory abilities against the host

Agrawal, Shivangi; Pathak, Ekta; Mishra, Rajeev; Mishra, Vibha; Parveen, Afifa; Mishra, Sunil Kumar; Byadgi, Parameswarappa S.; Dubey, Sushil Kumar; Chaudhary, Ashvanee Kumar; Singh, Vishwambhar; Chaurasia, Rameshwar Nath; Atri, Neelam (Elsevier Ltd, 2022-10)

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections generate approximately one million virions per day, and the majority of available antivirals are ineffective against it due to the virus's inherent ...
Bimetallic Au–Ag Nanoparticles: Advanced Nanotechnology for Tackling Antimicrobial Resistance

Singh, Chandrashekhar; Mehata, Abhishesh Kumar; Priya, Vishnu; Malik, Ankit Kumar; Setia, Aseem; Suseela, M. Nikitha Lakshmi; Vikas, M. Nikitha Lakshmi; Gokul, Patharaj; Samridhi, Patharaj; Singh, Sanjeev K.; Muthu, Madaswamy S. (MDPI, 2022-10)

To date, there are no antimicrobial agents available in the market that have absolute control over the growing threat of bacterial strains. The increase in the production capacity of antibiotics and the growing antibacterial ...
Molecular Mechanisms and Applications of N-Acyl Homoserine Lactone-Mediated Quorum Sensing in Bacteria

Kumar, Lokender; Patel, Sanjay Kumar Singh; Kharga, Kusum; Kumar, Rajnish; Kumar, Pradeep; Pandohee, Jessica; Kulshresha, Sourabh; Harjai, Kusum; Chhibber, Sanjay (MDPI,CODEN, MOLEF, 2022-11)

Microbial biodiversity includes biotic and abiotic components that support all life forms by adapting to environmental conditions. Climate change, pollution, human activity, and natural calamities affect microbial biodiversity. ...

Now showing items 41-60 of 178

Search in IDR

Advanced Search

Browse

All of IDR
This Collection
- By Issue Date
- Authors
- Titles
- Subjects

Recently added

Department of Pharmaceutical Engineering: Recent submissions

Search in IDR

Browse

All of IDR

This Collection

My Account