Department of Pharmaceutical Engineering: Recent submissions

Now showing items 1-20 of 178

Quality by design–based development and optimization of fourth-generation ternary solid dispersion of standardized Piper longum extract for melanoma therapy

Mohapatra, Debadatta; Kumar, Dulla Naveen; Shreya, Singh; Pandey, Vivek; Dubey, Pawan K.; Agrawal, Ashish Kumar; Sahu, Alakh N (Springer, 2023-06-09)

The study aimed to enhance the solubility, dissolution, and oral bioavailability of standardized Piper longum fruits ethanolic extract (PLFEE) via fourth-generation ternary solid dispersion (SD) for melanoma therapy. With ...
Fluorescence-tagged salivary small extracellular vesicles as a nanotool in early diagnosis of Parkinson’s disease

Rastogi, Simran; Rani, Komal; Rai, Sanskriti; Singh, Rishabh; Bharti, Prahalad Singh; Sharma, Vaibhav; Sahu, Jyoti; Kapoor, Vrinda; Vishwakarma, Poorvi; Garg, Sumit; Gholap, Shivajirao Lahu; Inampudi, Krishna Kishore; Modi, Gyan Prakash (BioMed Central Ltd, 2023-09-04)

Background: Parkinson’s disease is generally asymptomatic at earlier stages. At an early stage, there is an extensive progression in the neuropathological hallmarks, although, at this stage, diagnosis is not possible with ...
Machine Learning-Enabled NIR Spectroscopy. Part 3: Hyperparameter by Design (HyD) Based ANN-MLP Optimization, Model Generalizability, and Model Transferability

Ali, Hussain; Muthudoss, Prakash; Chauhan, Chirag; Kaliappan, Ilango; Kumar, Dinesh; Paudel, Amrit; Ramasamy, Gobi (Springer Science and Business Media Deutschland GmbH, 2023-12-07)

Data variations, library changes, and poorly tuned hyperparameters can cause failures in data-driven modelling. In such scenarios, model drift, a gradual shift in model performance, can lead to inaccurate predictions. ...
Phytochemical Screening, Acute Toxicity Study, and Pharmacological Evaluation of Natsiatum herpeticum Buch.Ham. ex Arn.

Hazarika, Sangeeta; Hemalatha, Siva; Venugopala, Katharigatta Narayanaswamy (Association of Pharmaceutical Teachers of India, 2023-12)

Background: Plants are an open treasure of diverse pharmacologically active scaffolds. Natsiatum herpeticum, a least exploited plant, is known to be consumed by various ethnic groups of Asian origin as edible or as part ...
Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice

Teeple, Kelsey; Rajput, Prabha; Scinto, Sara; Schoonmaker, Jenna; Davis, Corrin; Dinn, Michayla; McIntosh, Mackenzie; Krishnamurthy, Sairam; Plaut, Karen; Casey, Theresa (Company of Biologists Ltd, 2023-10)

Obesity and exposure to light at night are prevalent in modern society and associated with changes in physiology and behavior that can affect a female’s ability to support offspring growth during pregnancy and lactation. ...
Novel Gastroprotective and Thermostable Cocrystal of Dimethyl Fumarate: Its Preparation, Characterization, and In Vitro and In Vivo Evaluation

Alam, Qadir; Ganeshpurkar, Ankit; Singh, Sushil Kumar; Krishnamurthy, Sairam (American Chemical Society, 2023-07-11)

Crystallization has revolutionized the field of solid-state formulations by modulating the physiochemical and release profile of active pharmaceutical ingredients (APIs). Dimethyl fumarate (DF), an FDA-approved first-line ...
A Bacteriophage Microgel Effectively Treats the Multidrug-Resistant Acinetobacter baumannii Bacterial Infections in Burn Wounds

Dehari, Deepa; Chaudhuri, Aiswarya; Kumar, Dulla Naveen; Patil, Rohit; Gangwar, Mayank; Rastogi, Sonam; Kumar, Dinesh; Nath, Gopal; Agrawal, Ashish Kumar (Multidisciplinary Digital Publishing Institute (MDPI), 2023-06-29)

Multidrug-resistant (MDR) Acinetobacter baumannii (A. baumannii) is one of the major pathogens present in burn wound infections. Biofilm formation makes it further challenging to treat with clinically available antibiotics. ...
Immunogenicity Evaluation of Thermostable Microparticles Entrapping Receptor Binding Domain of SARS-CoV-2 by Single Point Administration

Ahuja, Rahul; Srichandan, Sudeepa; Meena, Jairam; Biswal, Bichitra Kumar; Panda, Amulya K. (Elsevier B.V., 2023-02-02)

Receptor binding domain (RBD) of SARS-CoV-2 is a prime vaccine target against which neutralizing antibody responses are directed. Purified RBD as a vaccine candidate warrants administration of multiple doses along with ...
Continuous Manufacturing of Cocrystals Using 3D-Printed Microfluidic Chips Coupled with Spray Coating

Kara, Aytug; Kumar, Dinesh; Healy, Anne Marie; Lalatsa, Aikaterini; Serrano, Dolores R. (Multidisciplinary Digital Publishing Institute (MDPI), 2023-07-27)

Using cocrystals has emerged as a promising strategy to improve the physicochemical properties of active pharmaceutical ingredients (APIs) by forming a new crystalline phase from two or more components. Particle size and ...
Vasicinone, a pyrroloquinazoline alkaloid from Adhatoda vasica Nees enhances memory and cognition by inhibiting cholinesterases in Alzheimer's disease

Bhanukiran, Kancharla; Singh, Ravi; T A, Gajendra; Ramakrishna, Kakarla; Singh, Sushil Kumar; Krishnamurthy, Sairam; Kumar, Ashok; Hemalatha, Siva (Elsevier B.V., 2023-03-30)

Background: Alzheimer's disease (AD) is a neurodegenerative disease with cognitive and memory decline. Due to the lack of effective treatment for AD, there is an interest in finding novel compounds to treat AD. The leaves ...
Pharmacological mechanism of indigenous herb Exacum lawii on cisplatin instigated toxicity in human embryonic kidney cells (HEK-293)

Sharma, Sonam (Elsevier B.V., 2023-04-21)

Background: Exacum lawii C.B. Clarke (Gentianaceae) bitter medicinal herb, has been extensively applied for the treatment of kidney diseases and ailments by Indigenous medical practitioners and local communities in Maharashtra ...
Effect of sulfonamide derivatives of phenylglycine on scopolamine-induced amnesia in rats

Ganeshpurkar, Ankit; Singh, Ravi; Tripathi, Pratigya; Alam, Qadir; Krishnamurthy, Sairam; Kumar, Ashok; Singh, Sushil K. (Wiley-VCH Verlag, 2023-03)

Alzheimer's disease is a neurodegenerative disease responsible for dementia and other neuropsychiatric symptoms. In the present study, compounds 30 and 33, developed earlier in our laboratory as selective butyrylcholinesterase ...
Development and Evaluation of Some Molecular Hybrids of N-(1-Benzylpiperidin-4-yl)-2-((5-phenyl-1,3,4-oxadiazol-2-yl)thio) as Multifunctional Agents to Combat Alzheimer’s Disease

Waiker, Digambar Kumar; Verma, Akash; Saraf, Poorvi; Gajendra, T.A.; Krishnamurthy, Sairam; Chaurasia, Rameshwar Nath; Shrivastava, Sushant Kumar (American Chemical Society, 2023-03-02)

A series of some novel compounds (SD-1-17) were designed following a molecular hybridization approach, synthesized, and biologically tested for hAChE, hBChE, hBACE-1, and Aβ aggregation inhibition potential to improve ...
Development and Evaluation of Bio fabricated Silver Nanoparticles from Blumea lacera for In-vitro Antibacterial, Antioxidant and Anti-inflammatory Activity

Dubey, Tarkeshwar; Bhanukiran, Kancharla; Das, Kuna; Hemalatha, Siva (EManuscript Technologies, 2023-03)

Background: Increasing prevalence of microbial resistance and side effects of currently available drugs compels the researchers to look for alternate therapies and formulations to overcome this problem. Plant based ...
Targeting lung macrophages for fungal and parasitic pulmonary infections with innovative amphotericin B dry powder inhalers

Kumar, D. (Elsevier B.V., 2023-03-01)

The incidence of fungal pulmonary infections is known to be on the increase, and yet there is an alarming gap in terms of marketed antifungal therapies that are available for pulmonary administration. Amphotericin B (AmB) ...
Comparative evaluation of two intranasal forms of Curcumin: Quantitation and impact on mouse model of asthma

Singh, Payal; Chawla, Ruchi; Pandey, Ajai Kumar; Mishra J.K.; Singh, Rashmi (Elsevier B.V., 2023-02-19)

Aim of the study: Present study aimed to investigate impact of two different intranasal forms of curcumin on mouse model of asthma and detection of its absorption after different time points of administration. Since the ...
Characterization of sow milk N-linked glycoproteome over the course of lactation

Rajput, Prabha; Aryal, Uma K.; Bhide, Ketaki; Minor, Radiah C.; Krishnamurthy, Sairam; Casey, Theresa M. (Oxford University Press, 2022-12-31)

Milk proteins serve as nutrition and affect neonate development and immunity through their bioactivity. Post-translational modifications of proteins affect their bioactivity. Glycosylation is the attachment of sugar moieties ...
Iodine-mediated one-step synthesis of ipomone from gibberellic acid

Goel, Bharat; Tripathi, Nancy; Bhardwaj, Nivedita; Jain, Shreyans K. (Taylor and Francis Ltd., 2022-04-16)

A fast and efficient method for synthesising ipomone (4), a bicyclo[3.2.1]octanone containing aromatised derivative, from gibberellic acid (1) has been developed using molecular iodine as a mild and effective mediator under ...
Oral Release Kinetics, Biodistribution, and Excretion of Dopants from Barium-Containing Bioactive Glass in Rats

Majumdar, Shreyasi; Tiwari, Anshul; Mallick, Debasmit; Patel, Devendra K.; Trigun, Surendra Kumar; Krishnamurthy, Sairam (American Chemical Society, 2024-01-31)

Background: Inorganic biomaterials are biologically active and are used as implants and drug delivery system. They have therapeutically active elements present in their framework that are released in the physiological ...
Integrated use of ligand and structure-based virtual screening, molecular dynamics, free energy calculation and ADME prediction for the identification of potential PTP1B inhibitors

Devi, Bharti; Vasishta, Sumukh Satyanarayana; Das, Bhanuranjan; Baidya, Anurag T. K.; Rampa, Rahul Salmon; Mahapatra, Manoj Kumar; Kumar, Rajnish (Institute for Ionics, 2023-02-06)

Protein tyrosine phosphatases (PTPs) are the group of enzymes that control both cellular activity and the dephosphorylation of tyrosine (Tyr)-phosphorylated proteins. Dysregulation of PTP1B has contributed to numerous ...

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