Browsing Department of Pharmaceutical Engineering by Author "Waiker, Digambar Kumar"

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Development and Evaluation of Some Molecular Hybrids of N-(1-Benzylpiperidin-4-yl)-2-((5-phenyl-1,3,4-oxadiazol-2-yl)thio) as Multifunctional Agents to Combat Alzheimer’s Disease

Waiker, Digambar Kumar; Verma, Akash; Saraf, Poorvi; Gajendra, T.A.; Krishnamurthy, Sairam; Chaurasia, Rameshwar Nath; Shrivastava, Sushant Kumar (American Chemical Society, 2023-03-02)

A series of some novel compounds (SD-1-17) were designed following a molecular hybridization approach, synthesized, and biologically tested for hAChE, hBChE, hBACE-1, and Aβ aggregation inhibition potential to improve ...
Synthesis, characterization, and biological evaluation of some novel ϒ-aminobutyric acid aminotransferase (GABA-AT) inhibitors

Shrivastava, Sushant Kumar; Sinha, Ojaswi; Kumar, Munish; Waiker, Digambar Kumar; Verma, Akash; Tripathi, Prabhash Nath; Bhardwaj, Bhagwati; Saraf, Poorvi (Springer, 2022-09)

In our present work, some novel substituted 4-phenyl-5-vinylpyrrolidin-2-one derivatives were designed, synthesized, and evaluated for their γ-aminobutyric acid-aminotransferase (GABA-AT) inhibition and in-vivo anticonvulsant ...

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