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Browsing Department of Pharmaceutical Engineering by Author "Vuddanda, Parameswara Rao"

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Development and Evaluation of Solid Lipid Nanoparticles of Raloxifene Hydrochloride for Enhanced Bioavailability

Kushwaha, Anand Kumar; Vuddanda, Parameswara Rao; Karunanidhi, Priyanka; and et al. (Hindawi Publishing Corporation, 2013-08-13)

Raloxifene hydrochloride (RL-HCL) is an orally selective estrogen receptor modulator (SERM) with poor bioavailability of nearly 2% due to its poor aqueous solubility and extensive first pass metabolism. In order to improve ...
Intestinal Lymphatic Delivery of Praziquantel by Solid Lipid Nanoparticles: Formulation Design, In Vitro and In Vivo Studies

Mishra, Amit; Vuddanda, Parameswara Rao; Singh, Sanjay (Hindawi Publishing Corporation, 2014-02-19)

The aim of the present work was to design and develop Praziquantal (PZQ) loaded solid lipid nanoparticles (PZQ-SLN) to improve the oral bioavailability by targeting intestinal lymphatic system. PZQ is practically insoluble ...
Investigations on Agglomeration and Haemocompatibility of Vitamin E TPGS Surface Modified Berberine Chloride Nanoparticles

Vuddanda, Parameswara Rao; Rajamanickam, Vijayakumar Mahalingam; Yaspal, Madhu; and et. al. (Hindawi Publishing Corporation, 2014-08-04)

The objective of the present study is to investigate the influence of surface modification on systemic stability of NPs. Vitamin E TPGS (1% w/v) was used for surface modification of berberine chloride nanoparticles. Naked ...
Pharmacokinetic and Tissue Distribution Study of Solid Lipid Nanoparticles of Zidovudine in Rats

Purvin, Shah; Vuddanda, Parameswara Rao; Singh, Sanjay Kumar; and et. al. (Hindawi Publishing Corporation, 2014-02-19)

idovudine-loaded solid lipid nanoparticles (AZT-SLNs) and zidovudine in solution were prepared and administered in rats. The aim of this research was to study whether the bioavailability of zidovudine can be improved by ...

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