Browsing Department of Pharmaceutical Engineering by Author "Jain, Shreyans K."

Browsing Department of Pharmaceutical Engineering by Author "Jain, Shreyans K."

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  • Antiproliferative Potential of Gloriosine: A Lead for Anticancer Drug Development 
    Goel, Bharat; Dey, Biswajit; Chatterjee, Essha; Tripathi, Nancy; Bhardwaj, Nivedita; Kumar, Sanjay; Guru, Santosh Kumar; Jain, Shreyans K. (American Chemical Society, 2022-08)
    Gloriosine, a colchicine-like natural product, is widely obtained from Gloriosa superba roots. Despite having remarkable anticancer potential, colchicine could not pave its way to the clinic, while gloriosine is yet to be ...
  • A comprehensive review on chemistry and pharmacology of marine bioactives as antimetastatic agents 
    Bhardwaj, Nivedita; Goel, Bharat; Tripathi, Nancy; Sahu, Bharat; Jain, Shreyans K. (Elsevier Masson s.r.l., 2022-04)
    Metastasis by and large is responsible for the worldwide deaths associated with various types of cancers. The metastatic variant of cancer cells generated due to the cellular heterogeneity and abnormal activation of various ...
  • Exploring the Potential of Chemical Inhibitors for Targeting Post-translational Glycosylation of Coronavirus (SARS-CoV-2) 
    Tripathi, Nancy; Goel, Bharat; Bhardwaj, Nivedita; Vishwakarma, Ram; Jain, Shreyans K. (American Chemical Society, 2022-08)
    The Spike (S) protein of SARS-CoV-2 expressed on the viral cell surface is of particular importance as it facilitates viral entry into the host cells. The S protein is heavily glycosylated with 22 N-glycosylation sites and ...
  • In silico analysis, isolation, and cytotoxicity evaluation of the coumestans from Cullen corylifolium (L.) Medik 
    Tripathi, Nancy; Shah, Himisa; Bhardwaj, Nivedita; Sarkar, Ruma; Jain, Shreyans K. (Taylor and Francis Ltd., 2023-11-27)
    Cullen corylifolium is well known for diverse phytoconstituents that possess multifaceted pharmacology, and one such less explored class is coumestans, which have not been well explored for their anticancer activities. One ...
  • Iodine-mediated one-step synthesis of ipomone from gibberellic acid 
    Goel, Bharat; Tripathi, Nancy; Bhardwaj, Nivedita; Kumar, Amit; Jain, Shreyans K. (Taylor and Francis Ltd., 2022-01)
    A fast and efficient method for synthesising ipomone (4), a bicyclo[3.2.1]octanone containing aromatised derivative, from gibberellic acid (1) has been developed using molecular iodine as a mild and effective mediator under ...
  • Iodine-mediated one-step synthesis of ipomone from gibberellic acid 
    Goel, Bharat; Tripathi, Nancy; Bhardwaj, Nivedita; Jain, Shreyans K. (Taylor and Francis Ltd., 2022-04-16)
    A fast and efficient method for synthesising ipomone (4), a bicyclo[3.2.1]octanone containing aromatised derivative, from gibberellic acid (1) has been developed using molecular iodine as a mild and effective mediator under ...
  • Isolation of a new cytotoxic colchinoid from Gloriosa superba roots 
    Goel, Bharat; Reddy, Harichander; Cholkar, Anjali; Kumar, Sanjeev; Guru, Santosh Kumar; Jain, Shreyans K. (Taylor and Francis Ltd., 2022)
    A new colchinoid compound, identified as N-deacetyl-N-formylcornigerine (1), named glorigerine was isolated from the roots of Gloriosa superba, along with two known compounds. The structures of isolated compounds were ...
  • Therapeutic approaches for the treatment of head and neck squamous cell carcinoma–An update on clinical trials 
    Goel, Bharat; Tiwari, Anoop Kumar; Pandey, Rajeev Kumar; Singh, Akhand Pratap; Kumar, Sujeet; Sinha, Abhishek; Jain, Shreyans K.; Khattri, Arun (Neoplasia Press, Inc., 2022-07)
    Head and neck squamous cell carcinoma (HNSCC) is the sixth most common non-skin cancer with a tobacco consumption and infection with high-risk human papillomavirus (HPV) being major risk factors. Despite advances in numerous ...

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