Abstract:
The present study was to assess the toxicity of hydro alcoholic leaves extract of Reinwardtia indica in Charles
foster rats through an acute and sub-acute study. In the acute study, rats were treated orally with single dose and
for sub-acute study different doses were given orally for 28 consecutive days. At the dose of 2000 mg/kg satellite
group was also used for 6 weeks as per OECD guidelines-407. General behavioral parameters were assessed in
acute toxicity and found no mortality or exterior signs of toxicity. While in the sub-acute study; biochemical,
hematological and histopathology along with the body weight, food, and water consumptions parameters were
screened in the animals after 14 & 28 days. The study reveals the insignificant (P < 0.05) change in treated
group in comparison to the control. The hydroalcoholic leaves extract of Reinwardtia indica was found non-toxic
up to 5000 mg/kg in acute study whereas up to 2000 mg/kg dose level in the sub-acute study.
