Iodine-mediated one-step synthesis of ipomone from gibberellic acid

Goel, Bharat; Tripathi, Nancy; Bhardwaj, Nivedita; Jain, Shreyans K.

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dc.contributor.author	Goel, Bharat
dc.contributor.author	Tripathi, Nancy
dc.contributor.author	Bhardwaj, Nivedita
dc.contributor.author	Jain, Shreyans K.
dc.date.accessioned	2024-02-22T10:03:03Z
dc.date.available	2024-02-22T10:03:03Z
dc.date.issued	2022-04-16
dc.identifier.issn	14786419
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/2966
dc.description	This paper published with affiliation IIT (BHU), Varanasi in Open Access Mode.	en_US
dc.description.abstract	A fast and efficient method for synthesising ipomone (4), a bicyclo[3.2.1]octanone containing aromatised derivative, from gibberellic acid (1) has been developed using molecular iodine as a mild and effective mediator under heating conditions in a single step. Evidence was obtained that the reaction simultaneously proceeds through aromatisation and pinacol-pinacolone type 1,2-alkyl shift. Use of excess iodine afforded iodomethyl derivative (5) that could serve as starting material for the synthesis of additional analogs.	en_US
dc.description.sponsorship	BG, NT, and NB are grateful to IIT (BHU), Varanasi, for providing teaching assistantship. The author(s) reported there is no funding associated with the work featured in this article.	en_US
dc.language.iso	en	en_US
dc.publisher	Taylor and Francis Ltd.	en_US
dc.relation.ispartofseries	Natural Product Research;37
dc.subject	1,2-alkyl shift	en_US
dc.subject	gibberellic acid	en_US
dc.subject	iodination	en_US
dc.subject	ipomone	en_US
dc.subject	natural product	en_US
dc.title	Iodine-mediated one-step synthesis of ipomone from gibberellic acid	en_US
dc.type	Article	en_US