Ethylcellulose inserts of an orphan drug for periodontitis: Preparation, in vitro, and clinical studies

dc.contributor.author	Barat, R.
dc.contributor.author	Srinatha, A.
dc.contributor.author	Pandit, J.K.
dc.contributor.author	Mittal, N.
dc.contributor.author	Anupurba, S.
dc.date.accessioned	2021-09-16T07:01:41Z
dc.date.available	2021-09-16T07:01:41Z
dc.date.issued	2007-11
dc.identifier.issn	15210464
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/1696
dc.description.abstract	Ethylcellulose inserts of niridazole fabricated by casting were studied for in vitro release and in vivo clinical effectiveness. The in vitro drug release was steady and sustained for over 7 days and followed diffusion kinetics. Selected batch, EN3, was evaluated clinically in patients with periodontitis for 6 months. A significant improvement (α ≤ 0.05) in clinical indices from baseline was observed. Intergroup study revealed a significant (α ≤ 0.01) change in the bleeding index, gingival index, plaque index, calculus criteria, and pocket depth. Significant reduction in total bacterial count in gingival crevicular fluid was observed before and postdevice insertion, as well as between control and treatment groups.	en_US
dc.description.sponsorship	Drug Delivery	en_US
dc.language.iso	en	en_US
dc.relation.ispartofseries	Issue 8;Volume 14
dc.subject	Casting Method;	en_US
dc.subject	Ethyl Cellulose;	en_US
dc.subject	Inserts;	en_US
dc.subject	Niridazole;	en_US
dc.subject	Periodontitis	en_US
dc.title	Ethylcellulose inserts of an orphan drug for periodontitis: Preparation, in vitro, and clinical studies	en_US
dc.type	Article	en_US