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Browsing Article by Author "Krishnamurthy, Sairam"

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Antihyperglycemic Activity of Houttuynia cordata Thunb. in Streptozotocin-Induced Diabetic Rats

Kumar, Manish; Prasad, Satyendra K.; Krishnamurthy, Sairam; and et. al. (Hindawi Publishing Corporation, 2014-02-24)

Present study is an attempt to investigate plausible mechanism involved behind antidiabetic activity of standardized Houttuynia cordata Thunb. extract in streptozotocin-induced diabetic rats. The plant is used as a medicinal ...
Characterization of sow milk N-linked glycoproteome over the course of lactation

Rajput, Prabha; Aryal, Uma K.; Bhide, Ketaki; Minor, Radiah C.; Krishnamurthy, Sairam; Casey, Theresa M. (Oxford University Press, 2022-12-31)

Milk proteins serve as nutrition and affect neonate development and immunity through their bioactivity. Post-translational modifications of proteins affect their bioactivity. Glycosylation is the attachment of sugar moieties ...
Combination Therapy Comprising Paclitaxel and 5-Fluorouracil by Using Folic Acid Functionalized Bovine Milk Exosomes Improves the Therapeutic Efficacy against Breast Cancer

Kumar, Dulla Naveen; Chaudhuri, Aiswarya; Dehari, Deepa; Shekher, Anusmita; Gupta, Subash C.; Majumdar, Shreyasi; Krishnamurthy, Sairam; Singh, Sanjay; Kumar, Dinesh; Agrawal, Ashish Kumar (MDPI, 2022-08)

Paclitaxel (PAC) has been approved by FDA for clinical use (Taxol®), yet dose-dependent severe toxicity due to the adjuvant Cremophor EL® in combination with ethanol is a major drawback. The drawbacks of the current therapy ...
Development and Evaluation of Some Molecular Hybrids of N-(1-Benzylpiperidin-4-yl)-2-((5-phenyl-1,3,4-oxadiazol-2-yl)thio) as Multifunctional Agents to Combat Alzheimer’s Disease

Waiker, Digambar Kumar; Verma, Akash; Saraf, Poorvi; Gajendra, T.A.; Krishnamurthy, Sairam; Chaurasia, Rameshwar Nath; Shrivastava, Sushant Kumar (American Chemical Society, 2023-03-02)

A series of some novel compounds (SD-1-17) were designed following a molecular hybridization approach, synthesized, and biologically tested for hAChE, hBChE, hBACE-1, and Aβ aggregation inhibition potential to improve ...
Diazepam Potentiates the Antidiabetic, Antistress and Anxiolytic Activities of Metformin in Type-2 Diabetes Mellitus with Cooccurring Stress in Experimental Animals

Garabadu, Debapriya; Krishnamurthy, Sairam (Hindawi Publishing Corporation, 2014-06-04)

Psychological stress is considered as one of the limiting factors in the management of type-2 diabetes mellitus (T2DM). Therefore, the basic objective of the present study was to evaluate the antidiabetic effect of metformin, ...
Dihydroquercetin ameliorates LPS-induced neuroinflammation and memory deficit

Alam, Qadir; Krishnamurthy, Sairam (Elsevier B.V., 2022-01)

Dihydroquercetin (DHQ) is a pentahydroxyflavanone that has been used as an important suppliment against oxidative stress related inflammation and neuroinflammation. Neuroinflammation, which is the activation of the defense ...
Effect of sulfonamide derivatives of phenylglycine on scopolamine-induced amnesia in rats

Ganeshpurkar, Ankit; Singh, Ravi; Tripathi, Pratigya; Alam, Qadir; Krishnamurthy, Sairam; Kumar, Ashok; Singh, Sushil K. (Wiley-VCH Verlag, 2023-03)

Alzheimer's disease is a neurodegenerative disease responsible for dementia and other neuropsychiatric symptoms. In the present study, compounds 30 and 33, developed earlier in our laboratory as selective butyrylcholinesterase ...
Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice

Teeple, Kelsey; Rajput, Prabha; Scinto, Sara; Schoonmaker, Jenna; Davis, Corrin; Dinn, Michayla; McIntosh, Mackenzie; Krishnamurthy, Sairam; Plaut, Karen; Casey, Theresa (Company of Biologists Ltd, 2023-10)

Obesity and exposure to light at night are prevalent in modern society and associated with changes in physiology and behavior that can affect a female’s ability to support offspring growth during pregnancy and lactation. ...
Indole-3-carbinol ameliorated the isoproterenol-induced myocardial infarction via multimodal mechanisms in Wistar rats

Ramakrishna, Kakarla; Krishnamurthy, Sairam (Taylor and Francis Ltd., 2022)

The present study investigated the cardioprotection of Indole-3-carbinol on isoproterenol (ISO)-induced myocardial infarction in Wistar rats. I3C treatment significantly reduced the prolongation of the QRS complex, QT ...
Metformin attenuates hepatic insulin resistance in type-2 diabetic rats through PI3K/Akt/GLUT-4 signalling independent to bicuculline-sensitive GABAA receptor stimulation

Garabadu, Debapriya; Krishnamurthy, Sairam (Taylor and Francis Ltd, 2017-01-01)

Context: Metformin attenuates type-2 diabetes mellitus (T2DM)-induced hepatic dysfunction and altered PI3K/Akt/GLUT-4 signalling in experimental studies. However, its effect on bicuculline-sensitive gamma amino butyric ...
Novel Gastroprotective and Thermostable Cocrystal of Dimethyl Fumarate: Its Preparation, Characterization, and In Vitro and In Vivo Evaluation

Alam, Qadir; Ganeshpurkar, Ankit; Singh, Sushil Kumar; Krishnamurthy, Sairam (American Chemical Society, 2023-07-11)

Crystallization has revolutionized the field of solid-state formulations by modulating the physiochemical and release profile of active pharmaceutical ingredients (APIs). Dimethyl fumarate (DF), an FDA-approved first-line ...
Oral Release Kinetics, Biodistribution, and Excretion of Dopants from Barium-Containing Bioactive Glass in Rats

Majumdar, Shreyasi; Tiwari, Anshul; Mallick, Debasmit; Patel, Devendra K.; Trigun, Surendra Kumar; Krishnamurthy, Sairam (American Chemical Society, 2024-01-31)

Background: Inorganic biomaterials are biologically active and are used as implants and drug delivery system. They have therapeutically active elements present in their framework that are released in the physiological ...
Vasicinone, a pyrroloquinazoline alkaloid from Adhatoda vasica Nees enhances memory and cognition by inhibiting cholinesterases in Alzheimer's disease

Bhanukiran, Kancharla; Singh, Ravi; T A, Gajendra; Ramakrishna, Kakarla; Singh, Sushil Kumar; Krishnamurthy, Sairam; Kumar, Ashok; Hemalatha, Siva (Elsevier B.V., 2023-03-30)

Background: Alzheimer's disease (AD) is a neurodegenerative disease with cognitive and memory decline. Due to the lack of effective treatment for AD, there is an interest in finding novel compounds to treat AD. The leaves ...

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