Browsing Article by Author "Giri, D."

Browsing Article by Author "Giri, D."

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  • Effects of molecular crowding on stretching of polymers in poor solvent 
    Singh, A.R.; Giri, D.; Kumar, S. (2009-05-11)
    We consider a linear polymer chain in a disordered environment modeled by percolation clusters on a square lattice. The disordered environment is meant to roughly represent molecular crowding as seen in cells. The model ...
  • Force induced melting of the constrained DNA 
    Singh, A.R.; Giri, D.; Kumar, S. (2010-06-21)
    We develop a simple model to study the effects of the applied force on the melting of a double stranded DNA (dsDNA). Using this model, we could study the stretching, unzipping, rupture and slippagelike transition in a ...
  • Force induced unfolding of biopolymers in a cellular environment: A model study 
    Singh, A.R.; Giri, D.; Kumar, S. (2009)
    Effect of molecular crowding and confinement experienced by protein in the cell during unfolding has been studied by modeling a linear polymer chain on a percolation cluster. It is known that internal structure of the cell ...
  • Role of loop entropy in the force induced melting of DNA hairpin 
    Mishra, G.; Giri, D.; Li, M.S.; Kumar, S. (2011-07-21)
    Dynamics of a single stranded DNA, which can form a hairpin have been studied in the constant force ensemble. Using Langevin dynamics simulations, we obtained the force-temperature diagram, which differs from the theoretical ...
  • Role of pulling direction in understanding the energy landscape of proteins 
    Rajesh, R.; Giri, D.; Jensen, I.; Kumar, S. (2008-08-13)
    Single-molecule force spectroscopy provide details of the underlying energy surfaces of proteins which are essential to the understanding of their unfolding process. Recently, it has been observed experimentally that by ...
  • Stretching of a single-stranded DNA 
    Mishra, G.; Giri, D.; Kumar, S. (2009-03-03)
    Recent experiments have shown that the force-extension (F-x) curve for single-stranded DNA (ssDNA) consisting only of adenine [poly(dA)] is significantly different from thymine [poly(dT)]. Here, we show that the base ...

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