Browsing Article by Author "Dubey, Vikash Kumar"

Browsing Article by Author "Dubey, Vikash Kumar"

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  • Biochemical characterization and chemical validation of Leishmania MAP Kinase-3 as a potential drug target 
    Raj, Shweta; Saha, Gundappa; Sasidharan, Santanu; Dubey, Vikash Kumar; Saudagar, Prakash (Nature Publishing Group, 2019-12-01)
    Protozoan parasites of the Leishmania genus have evolved unique signaling pathways that can sense various environmental changes and trigger stage differentiation for survival and host infectivity. MAP kinase (MAPK) plays ...
  • Drug Encapsulated Lipid-Polymeric Nanohybrid as a Chemo-therapeutic Platform of Cancer 
    Kumar, Rahul; Ranjan Srivastava, Vinish; Mahapatra, Supratim; Dkhar, Daphika S.; Kumari, Rohini; Darshna; Prerna, Kumari; Dubey, Vikash Kumar; Chandra, Pranjal (Ivyspring International Publisher, 2023-01-16)
    The focus of this research is to design a bioengineered drug delivery vehicle that is efficient in anti-cancer drug delivery in a controlled manner. The experimental work focuses on constructing a methotrexate-loaded nano ...
  • Dual-target drugs against Leishmania donovani for potential novel therapeutics 
    Bora, Kushal; Sarma, Manash; Kanaujia, Shankar Prasad; Dubey, Vikash Kumar (Nature Research, 2023-10-26)
    Antioxidant defense mechanisms are important for a parasite to overcome oxidative stress and survive within host macrophage cells. Mitochondrial iron superoxide dismutase A (FeSODA) and trypanothione reductase (TR) are ...
  • Ligand conjugated lipid-based nanocarriers for cancer theranostics 
    Kumar, Rahul; Dkhar, Daphika S.; Kumari, Rohini; Divya; Mahapatra, Supratim; Srivastava, Ananya; Dubey, Vikash Kumar; Chandra, Pranjal (John Wiley and Sons Inc, 2022-11)
    Cancer is one of the major health-related issues affecting the population worldwide and subsequently accounts for the second-largest death. Genetic and epigenetic modifications in oncogenes or tumor suppressor genes affect ...
  • Repurposing of FDA-approved drugs as autophagy inhibitors in tumor cells 
    Prerna, Kumari; Dubey, Vikash Kumar (Taylor and Francis Ltd. CODEN, 2022)
    Autophagy and apoptosis are the two crucial processes of programmed cell death found in all eukaryotic cells; however, the elevated physiological stress in the tumor microenvironment leads to uncontrolled up-regulation in ...

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