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Now showing items 95-114 of 178

Identification and validation of core genes as promising diagnostic signature in hepatocellular carcinoma based on integrated bioinformatics approach

Kumar, Pradeep; Singh, Amit Kumar; Tiwari, Kavindra Nath; Mishra, Sunil Kumar; Rajput, Vishnu D.; Minkina, Tatiana; Cavalu, Simona; Pop, Ovidiu (Nature Research, 2022-12)

The primary objective of this investigation was to determine the hub genes of hepatocellular carcinoma (HCC) through an in silico approach. In the current context of the increased incidence of liver cancers, this approach ...
Immunogenicity Evaluation of Thermostable Microparticles Entrapping Receptor Binding Domain of SARS-CoV-2 by Single Point Administration

Ahuja, Rahul; Srichandan, Sudeepa; Meena, Jairam; Biswal, Bichitra Kumar; Panda, Amulya K. (Elsevier B.V., 2023-02-02)

Receptor binding domain (RBD) of SARS-CoV-2 is a prime vaccine target against which neutralizing antibody responses are directed. Purified RBD as a vaccine candidate warrants administration of multiple doses along with ...
Impact of high-fat diet and exposure to constant light on reproductive competence of female ICR mice

Teeple, Kelsey; Rajput, Prabha; Scinto, Sara; Schoonmaker, Jenna; Davis, Corrin; Dinn, Michayla; McIntosh, Mackenzie; Krishnamurthy, Sairam; Plaut, Karen; Casey, Theresa (Company of Biologists Ltd, 2023-10)

Obesity and exposure to light at night are prevalent in modern society and associated with changes in physiology and behavior that can affect a female’s ability to support offspring growth during pregnancy and lactation. ...
The Impact of obesity and diabetes mellitus on pancreatic cancer: Molecular mechanisms and clinical perspectives

Quoc Lam, B.; Shrivastava, S.K.; Shrivastava, A.; Shankar, S.; Srivastava, R.K. (Blackwell Publishing Inc., 2020-07-01)

The incidence of obesity and type 2 diabetes (T2DM) in the Western world has increased dramatically during the recent decades. According to the American Cancer Society, pancreatic cancer (PC) is the fourth leading cause ...
Implication of linker length on cell cytotoxicity, pharmacokinetic and toxicity profile of gemcitabine-docetaxel combinatorial dual drug conjugate

Kushwah, V.; Katiyar, S.S.; Agrawal, A.K.; Saraf, I.; Singh, I.P.; Lamprou, D.A.; Gupta, R.C. (Elsevier B.V., 2018-09-05)

The present study investigates effect of linkers [zero length (without linker), short length linker (glycine and lysine) and long length linker (PEG1000, PEG2000 and PEG3500)] on pharmacokinetics and toxicity of docetaxel ...
Improved Aqueous Solubility and Antihypercholesterolemic Activity of Ezetimibe on Formulating with Hydroxypropyl-β-Cyclodextrin and Hydrophilic Auxiliary Substances

Srivalli, Kale Mohana Raghava; Mishra, Brahmeshwar (Springer New York LLC, 2015-06-16)

The purpose of this study was to improve the aqueous solubility, dissolution, and pharmacodynamic properties of a BCS class II drug, ezetimibe (Eze) by preparing ternary cyclodextrin complex systems. We investigated the ...
In silico analysis, isolation, and cytotoxicity evaluation of the coumestans from Cullen corylifolium (L.) Medik

Tripathi, Nancy; Shah, Himisa; Bhardwaj, Nivedita; Sarkar, Ruma; Jain, Shreyans K. (Taylor and Francis Ltd., 2023-11-27)

Cullen corylifolium is well known for diverse phytoconstituents that possess multifaceted pharmacology, and one such less explored class is coumestans, which have not been well explored for their anticancer activities. One ...
In situ forming formulation: Development, evaluation, and optimization using 33 factorial design

Nagarwal, R.C.; Srinatha, A.; Pandit, J.K. (2009-09)

The present investigation concerns with the development and optimization of an in situ forming formulation using 33 full factorial design experimentation. Metformin, an antidiabetic drug with upper part of gastrointestinal ...
In Vitro Study on Glucose Utilization Capacity of Bioactive Fractions of Houttuynia cordata in Isolated Rat Hemidiaphragm and Its Major Phytoconstituent

Kumar, Manish; Prasad, Satyendra K.; Hemalatha, Siva (Hindawi Limited, 2015-12-28)

Objective. The whole plant of Houttuynia cordata has been reported to have potent antihyperglycemic activity. Therefore, the present study was undertaken to investigate the glucose utilization capacity of bioactive fractions ...
Indole-3-carbinol ameliorated the isoproterenol-induced myocardial infarction via multimodal mechanisms in Wistar rats

Ramakrishna, Kakarla; Krishnamurthy, Sairam (Taylor and Francis Ltd., 2022)

The present study investigated the cardioprotection of Indole-3-carbinol on isoproterenol (ISO)-induced myocardial infarction in Wistar rats. I3C treatment significantly reduced the prolongation of the QRS complex, QT ...
Indole: A promising scaffold for the discovery and development of potential anti-tubercular agents

Bajad, Nilesh Gajanan; Singh, Sudhir Kumar; Singh, Sushil Kumar; Singh, Tryambak Deo; Singh, Meenakshi (Elsevier B.V., 2022-01)

Indole-containing small molecules have been reported to have diverse pharmacological activities. The aromatic heterocyclic scaffold, which resembles various protein structures, has received attention from organic and ...
Integrated use of ligand and structure-based virtual screening, molecular dynamics, free energy calculation and ADME prediction for the identification of potential PTP1B inhibitors

Devi, Bharti; Vasishta, Sumukh Satyanarayana; Das, Bhanuranjan; Baidya, Anurag T. K.; Rampa, Rahul Salmon; Mahapatra, Manoj Kumar; Kumar, Rajnish (Institute for Ionics, 2023-02-06)

Protein tyrosine phosphatases (PTPs) are the group of enzymes that control both cellular activity and the dephosphorylation of tyrosine (Tyr)-phosphorylated proteins. Dysregulation of PTP1B has contributed to numerous ...
Intestinal Lymphatic Delivery of Praziquantel by Solid Lipid Nanoparticles: Formulation Design, In Vitro and In Vivo Studies

Mishra, Amit; Vuddanda, Parameswara Rao; Singh, Sanjay (Hindawi Publishing Corporation, 2014-02-19)

The aim of the present work was to design and develop Praziquantal (PZQ) loaded solid lipid nanoparticles (PZQ-SLN) to improve the oral bioavailability by targeting intestinal lymphatic system. PZQ is practically insoluble ...
Intranasally Co-administered Berberine and Curcumin Loaded in Transfersomal Vesicles Improved Inhibition of Amyloid Formation and BACE-1

Mishra, Gaurav; Awasthi, Rajendra; Singh, Anurag Kumar; Singh, Snigdha; Mishra, Sunil Kumar; Singh, Santosh Kumar; Nandi, Manmath K. (American Chemical Society, 2022-11)

Selective permeability of the blood-brain barrier restricts the treatment efficacy of neurologic diseases. Berberine (BBR) and curcumin (CUR)-loaded transferosomes (TRANS) were prepared for the effective management of ...
Investigation of organoleptic characteristics in the development of soft chews of calcium carbonate as mineral supplement

Mishra, B.; Sharma, G.; Shukla, D. (2009-12)

The present study was aimed at developing a soft chewable dosage form for calcium carbonate for nutraceutical application. Two different types of the formulations viz., sugar based and sugar free soft chews were prepared. ...
Investigations on Agglomeration and Haemocompatibility of Vitamin E TPGS Surface Modified Berberine Chloride Nanoparticles

Vuddanda, Parameswara Rao; Rajamanickam, Vijayakumar Mahalingam; Yaspal, Madhu; and et. al. (Hindawi Publishing Corporation, 2014-08-04)

The objective of the present study is to investigate the influence of surface modification on systemic stability of NPs. Vitamin E TPGS (1% w/v) was used for surface modification of berberine chloride nanoparticles. Naked ...
Iodine-mediated one-step synthesis of ipomone from gibberellic acid

Goel, Bharat; Tripathi, Nancy; Bhardwaj, Nivedita; Kumar, Amit; Jain, Shreyans K. (Taylor and Francis Ltd., 2022-01)

A fast and efficient method for synthesising ipomone (4), a bicyclo[3.2.1]octanone containing aromatised derivative, from gibberellic acid (1) has been developed using molecular iodine as a mild and effective mediator under ...
Iodine-mediated one-step synthesis of ipomone from gibberellic acid

Goel, Bharat; Tripathi, Nancy; Bhardwaj, Nivedita; Jain, Shreyans K. (Taylor and Francis Ltd., 2022-04-16)

A fast and efficient method for synthesising ipomone (4), a bicyclo[3.2.1]octanone containing aromatised derivative, from gibberellic acid (1) has been developed using molecular iodine as a mild and effective mediator under ...
Ion-activated in situ gelling systems for sustained ophthalmic delivery of ciprofloxacin hydrochloride

Balasubramaniam, J.; Pandit, J.K. (Taylor and Francis Inc., 2003-09)

The poor bioavailability and therapeutic response exhibited by the conventional ophthalmic solutions due to precorneal elimination of the drug may be overcome by the use of in situ gel forming systems that are instilled ...
Isolation of a new cytotoxic colchinoid from Gloriosa superba roots

Goel, Bharat; Reddy, Harichander; Cholkar, Anjali; Kumar, Sanjeev; Guru, Santosh Kumar; Jain, Shreyans K. (Taylor and Francis Ltd., 2022)

A new colchinoid compound, identified as N-deacetyl-N-formylcornigerine (1), named glorigerine was isolated from the roots of Gloriosa superba, along with two known compounds. The structures of isolated compounds were ...

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