Axisymmetric bis-tridentate Ir(iii) photoredox catalysts for anticancer phototherapy under hypoxia

Wei, Li; Kushwaha, Rajesh; Dao, Anyi; Fan, Zhongxian; Banerjee, Samya; Huang, Huaiyi

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dc.contributor.author	Wei, Li
dc.contributor.author	Kushwaha, Rajesh
dc.contributor.author	Dao, Anyi
dc.contributor.author	Fan, Zhongxian
dc.contributor.author	Banerjee, Samya
dc.contributor.author	Huang, Huaiyi
dc.date.accessioned	2024-03-14T11:29:46Z
dc.date.available	2024-03-14T11:29:46Z
dc.date.issued	2023-02-14
dc.identifier.issn	13597345
dc.identifier.uri	http://localhost:8080/xmlui/handle/123456789/2988
dc.description	This paper published with affiliation IIT (BHU), Varanasi in open access mode.	en_US
dc.description.abstract	A novel axisymmetric bis-tridentate Ir(iii) photocatalyst (Ir3) with synergetic type I/II photosensitization and photocatalytic activity was reported. Ir3 exhibited high photocytotoxicity toward drug-resistant cancer cells under normoxia and hypoxia. The photoactivated anticancer mechanism of Ir3 were investigated in detail. Overall, this new photo-redox catalyst can overcome hypoxia and drug resistance-related problems in clinical anticancer therapy.	en_US
dc.description.sponsorship	We appreciate the financial support from the National Natural Science Foundation of China (NSFC 22277153, 22007104), Guangdong Basic and Applied Basic Research Foundation (2021B1515020050), the Fundamental Research Funds for the Central Universities (22lgqb37), the Science, Technology and Innovation Commission of Shenzhen Municipality (JCYJ20190807152616996), and SERB (SRG/2022/000030), the Government of India. R. Kushwaha thanks the Ministry of Education, the Government of India for the Prime Minister’s Research Fellowship.	en_US
dc.language.iso	en	en_US
dc.publisher	Royal Society of Chemistry	en_US
dc.relation.ispartofseries	Chemical Communications;59
dc.subject	Antineoplastic Agents	en_US
dc.subject	Catalysis	en_US
dc.subject	Humans	en_US
dc.subject	Hypoxia	en_US
dc.subject	Phototherapy	en_US
dc.title	Axisymmetric bis-tridentate Ir(iii) photoredox catalysts for anticancer phototherapy under hypoxia	en_US
dc.type	Article	en_US