Abstract:
The thesis entitled “In silico Study, Synthesis and Biological Screening of Some Novel
Curcumin” submitted for the award of the degree of Doctor of Philosophy (Ph.D.) contains
the research work carried out during the period of July 2010 to October 2015, at the
Department of Pharmaceutics, Indian Institute of Technology, Banaras Hindu University,
Varanasi, India under the supervision of Prof. (Dr.) Sushil Kumar Singh. This thesis
contains an introduction, a literature review, detailed procedures for the synthesis of
designed compounds, and their characterization by physicochemical and spectroscopic
methods. Biological evaluation includes antimicrobial and antimalarial activities of the
compounds. The antimicrobial results were presented with MIC values. The anti-malarial
the activity was performed by the method of Trager and Jensen with minor modifications.
Full abstract is available in the attachment.
