Abstract:
Abstract
Department of Pharmaceutics, IIT (BHU), Varanasi iii
However, some of the potent compounds were found to be hepatotoxic (NTA-18 and
HPO-7).
Molecular property analysis and ADME/T studies showed satisfactory results for oral
administration, since the compounds satisfied Lipinski’s parameters and possessed
drug-like characteristics and ADMET profile.
Further studies like lead optimization, co-crystallization of lead inhibitors with MAO
or AChE enzymes, in-vitro butyryl cholinesterase (BuChE) enzyme inhibition study,
determination of metal-chelation property etc. on these lead compounds are essential
to further develop them as potential MAOIs and/or AChEIs or dual MAO-AChE
inhibitors for the treatment of NDDs.
