Browsing by Subject "Wnt/β-catenin signaling"

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Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting β-catenin/TCF4 signaling pathway

Neogi, Kaushik; Murumkar, Prashant R.; Sharma, Priyanshu; Yadav, Poonam; Tewari, Mallika; Karunagaran, Devarajan; Nayak, Prasanta Kumar; Yadav, Mange Ram (Neoplasia Press, Inc., 2022-05)

Overactivation of Wnt/β-catenin signaling by accumulated β-catenin in the nucleus has been shown to play a crucial role in the etiology of cancer. Interaction of β-catenin with Transcription factor 4 (TCF4) is a key step ...
Transcription factor 4 expression and correlation with tumor progression in gallbladder cancer

Neogi, Kaushik; Tewari, Mallika; Singh, Ashish Kumar; Sharma, Kavyanjali; Tej, Gullanki Naga Venkata Charan; Verma, Sumit Singh; Gupta, Subash Chandra; Nayak, Prasanta Kumar (Wolters Kluwer Medknow Publications, 2022-04)

Dysregulation in Wnt/β-catenin signaling has been associated with the initiation and metastasis of cancer cells. Transcription factor 4 (TCF4) (also named as transcription factor 7-like 2) is a key transcriptional factor ...

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