Browsing by Author "Neogi, Kaushik"

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Design, synthesis and evaluation of 4,7-disubstituted 8-methoxyquinazoline derivatives as potential cytotoxic agents targeting β-catenin/TCF4 signaling pathway

Neogi, Kaushik; Murumkar, Prashant R.; Sharma, Priyanshu; Yadav, Poonam; Tewari, Mallika; Karunagaran, Devarajan; Nayak, Prasanta Kumar; Yadav, Mange Ram (Neoplasia Press, Inc., 2022-05)

Overactivation of Wnt/β-catenin signaling by accumulated β-catenin in the nucleus has been shown to play a crucial role in the etiology of cancer. Interaction of β-catenin with Transcription factor 4 (TCF4) is a key step ...
Therapeutic potential of Wnt/β-catenin/TCF4 signaling pathway downregulators against gallbladder cancer

Neogi, Kaushik (IIT (BHU) Varanasi, 2022)

Gallbladder cancer (GBC) is the most common malignancy of the biliary tract, ranked sixth among gastrointestinal cancers, and is associated with a poor prognosis. According to GLOBOCAN 2018 data, globally about 219420 GBC ...
Transcription factor 4 expression and correlation with tumor progression in gallbladder cancer

Neogi, Kaushik; Tewari, Mallika; Singh, Ashish Kumar; Sharma, Kavyanjali; Tej, Gullanki Naga Venkata Charan; Verma, Sumit Singh; Gupta, Subash Chandra; Nayak, Prasanta Kumar (Wolters Kluwer Medknow Publications, 2022-04)

Dysregulation in Wnt/β-catenin signaling has been associated with the initiation and metastasis of cancer cells. Transcription factor 4 (TCF4) (also named as transcription factor 7-like 2) is a key transcriptional factor ...

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